TY  - GEN
AB  - This study investigated how kainate receptors (KARs) are targeted to hippocampal interneuron synapses in CA1. Interneurons in stratum radiatum/lacunosum‑moleculare expressed somatodendritic KARs with and without GluR5, but only GluR5‑containing KARs contributed to synaptic EPSCs. AMPA receptors also generated a slow EPSC tail current, which did not appear in spontaneous events, suggesting receptor segregation across synapses. The slow tail reflected intrinsic AMPAR kinetics rather than glutamate spillover. In stratum oriens interneurons, GluR5‑KARs were extrasynaptic and did not contribute to EPSCs. Findings indicate cell‑type, synapse‑specific, and subunit‑dependent KAR localization.
AD  - Oregon Health and Science University
AU  - Wondolowski, Joyce
DA  - 2009
DO  - 10.6083/M4GM859H
DO  - DOI
ED  - Frerking, Matthew
ED  - Mentor
ID  - 684
KW  - Interneurons
KW  - Kainic Acid
KW  - Hippocampus
KW  - Synapses
KW  - Receptors, Kainic Acid
L1  - https://digitalcollections.ohsu.edu/record/684/files/685_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/684/files/685_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/684/files/685_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/684/files/685_etd.pdf
N2  - This study investigated how kainate receptors (KARs) are targeted to hippocampal interneuron synapses in CA1. Interneurons in stratum radiatum/lacunosum‑moleculare expressed somatodendritic KARs with and without GluR5, but only GluR5‑containing KARs contributed to synaptic EPSCs. AMPA receptors also generated a slow EPSC tail current, which did not appear in spontaneous events, suggesting receptor segregation across synapses. The slow tail reflected intrinsic AMPAR kinetics rather than glutamate spillover. In stratum oriens interneurons, GluR5‑KARs were extrasynaptic and did not contribute to EPSCs. Findings indicate cell‑type, synapse‑specific, and subunit‑dependent KAR localization.
PB  - Oregon Health and Science University
PY  - 2009
T1  - Cell type selective expression of a slow AMPA/kainate EPSC in hippocampal interneurons
TI  - Cell type selective expression of a slow AMPA/kainate EPSC in hippocampal interneurons
UR  - https://digitalcollections.ohsu.edu/record/684/files/685_etd.pdf
Y1  - 2009
ER  -