000000684 001__ 684
000000684 005__ 20260410124450.0
000000684 0247_ $$2DOI$$a10.6083/M4GM859H
000000684 037__ $$aETD
000000684 245__ $$aCell type selective expression of a slow AMPA/kainate EPSC in hippocampal interneurons
000000684 260__ $$bOregon Health and Science University
000000684 269__ $$a2009
000000684 336__ $$aDissertation
000000684 502__ $$bPh.D.
000000684 502__ $$gNeuroscience
000000684 520__ $$aThis study investigated how kainate receptors (KARs) are targeted to hippocampal interneuron synapses in CA1. Interneurons in stratum radiatum/lacunosum‑moleculare expressed somatodendritic KARs with and without GluR5, but only GluR5‑containing KARs contributed to synaptic EPSCs. AMPA receptors also generated a slow EPSC tail current, which did not appear in spontaneous events, suggesting receptor segregation across synapses. The slow tail reflected intrinsic AMPAR kinetics rather than glutamate spillover. In stratum oriens interneurons, GluR5‑KARs were extrasynaptic and did not contribute to EPSCs. Findings indicate cell‑type, synapse‑specific, and subunit‑dependent KAR localization.
000000684 540__ $$fCC BY
000000684 542__ $$fIn copyright - single owner
000000684 650__ $$aInterneurons$$020936
000000684 650__ $$aKainic Acid$$021133
000000684 650__ $$aHippocampus$$020217
000000684 650__ $$aSynapses$$026704
000000684 650__ $$aReceptors, Kainic Acid$$030498
000000684 691__ $$aSchool of Medicine$$041369
000000684 692__ $$aVollum Institute$$041509
000000684 7001_ $$aWondolowski, Joyce$$uOregon Health and Science University$$041354
000000684 7201_ $$aFrerking, Matthew$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000684 8564_ $$9d5382aea-4e5a-4675-8979-0fbe8b456a3d$$s5565808$$uhttps://digitalcollections.ohsu.edu/record/684/files/685_etd.pdf$$ePublic$$28c195eb14a391db61c4ae1035ac1d456$$31
000000684 901__ $$a&lt;p&gt;These documents are archival records. They are retained for historical reference only. &lt;/p&gt;&lt;p&gt;&lt;b&gt;Need an accessible version? Use the ‘Get Accessible Copy’ link above.&lt;/b&gt;&lt;/p&gt;
000000684 905__ $$a/rest/prod/76/53/71/38/76537138x
000000684 909CO $$ooai:digitalcollections.ohsu.edu:684$$pstudent-work
000000684 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000684 980__ $$aTheses and Dissertations