000000693 001__ 693
000000693 005__ 20260130125632.0
000000693 0247_ $$2DOI$$a10.6083/M49Z92W5
000000693 037__ $$aETD
000000693 245__ $$aThe role of apolipoprotein E isoform and reactive oxygen species on the cognitive function of female mice following cranial irradiation
000000693 260__ $$bOregon Health and Science University
000000693 269__ $$a2011
000000693 336__ $$aDissertation
000000693 502__ $$bPh.D.
000000693 502__ $$gBehavioral & Systems Neuroscience
000000693 520__ $$aRadiation exposure can impair cognition, particularly hippocampal‑dependent learning and memory, yet susceptibility varies, suggesting genetic influences. This work examined whether apoE isoforms and reactive oxygen species (ROS) contribute to radiation‑induced cognitive outcomes in female mice and whether effects differ by radiation type. ApoE4 mice showed improved spatial memory after ¹³⁷Cs irradiation, accompanied by enhanced PMA‑induced ROS, while apoE2 mice did not. In contrast, ⁵⁶Fe irradiation did not enhance spatial memory but improved contextual fear conditioning without increasing ROS. These findings demonstrate that cognitive effects of irradiation depend on apoE isoform, radiation type, and memory domain, and highlight a role for stimulus‑induced ROS in radiation‑related cognitive changes.
000000693 540__ $$fCC BY
000000693 542__ $$fIn copyright - single owner
000000693 650__ $$aApolipoproteins E$$014992
000000693 650__ $$aCranial Irradiation$$029107
000000693 650__ $$aCognition$$016868
000000693 650__ $$aHippocampus$$020217
000000693 650__ $$aMice$$036842
000000693 650__ $$aReactive Oxygen Species$$029926
000000693 650__ $$aSpatial Memory$$040736
000000693 650__ $$aReactive Oxygen Species$$029926
000000693 650__ $$aAnimals, Laboratory$$014782
000000693 650__ $$aApolipoprotein E4$$037353
000000693 650__ $$aApolipoprotein E2$$037354
000000693 691__ $$aSchool of Medicine$$041369
000000693 692__ $$aDepartment of Behavioral Neuroscience$$041394
000000693 7001_ $$aVillasana, Laura$$uOregon Health and Science University$$041354
000000693 7201_ $$aRaber, Jacob$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000693 8564_ $$995d40afb-be9a-441f-aaf1-f3c0f6db0a84$$s16583165$$uhttps://digitalcollections.ohsu.edu/record/693/files/694_etd.pdf$$ePublic$$287fe76da985c1cbde1389737aae9da4c$$31
000000693 905__ $$a/rest/prod/1n/79/h4/31/1n79h431q
000000693 909CO $$ooai:digitalcollections.ohsu.edu:693$$pstudent-work
000000693 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000693 980__ $$aTheses and Dissertations