000000697 001__ 697
000000697 005__ 20260120144837.0
000000697 0247_ $$2DOI$$a10.6083/M4SX6B6C
000000697 037__ $$aETD
000000697 245__ $$aRole of cell adhesion molecule CD166 in homeostatic maintenance and regeneration of the intestinal stem cell niche
000000697 260__ $$bOregon Health and Science University
000000697 269__ $$a2011
000000697 336__ $$aThesis
000000697 502__ $$bPh.D.
000000697 502__ $$gCell & Developmental Biology (sunsetting)
000000697 520__ $$aThe intestinal epithelium renews rapidly through tightly regulated stem cell activity within the crypt niche. The adhesion molecule CD166, a colorectal cancer stem cell marker, has an unclear role in normal intestine. We found CD166 expression localized to Lgr5-positive stem/progenitor cells and Paneth cells, suggesting a niche-regulatory function. CD166‑null mice showed impaired proliferation, Wnt signaling, migration, reduced stem cell numbers, and smaller crypts, as well as delayed recovery after radiation injury. These findings identify CD166 as a key regulator of intestinal stem cell homeostasis with implications for epithelial regeneration and cancer.
000000697 540__ $$fCC BY
000000697 542__ $$fIn copyright - single owner
000000697 650__ $$aIntestines$$020963
000000697 650__ $$aStem Cells$$026391
000000697 650__ $$aActivated-Leukocyte Cell Adhesion Molecule$$032397
000000697 650__ $$aRectum$$025241
000000697 650__ $$aCell Adhesion Molecules$$028673
000000697 650__ $$aColorectal Neoplasms$$028197
000000697 650__ $$aNeoplastic Stem Cells$$027504
000000697 650__ $$aColon$$016901
000000697 6531_ $$acancer
000000697 691__ $$aSchool of Medicine$$041369
000000697 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000000697 7001_ $$aLevin, Trevor$$uOregon Health and Science University$$041354
000000697 7201_ $$aWong, Melissa$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000697 8564_ $$9736408ae-bb9c-4564-8123-869302353a46$$s4216856$$uhttps://digitalcollections.ohsu.edu/record/697/files/698_etd.pdf$$ePublic$$23e84700ada44a6c0dc8c1fa0da1e9f89$$31
000000697 905__ $$a/rest/prod/vq/27/zn/45/vq27zn45k
000000697 909CO $$ooai:digitalcollections.ohsu.edu:697$$pstudent-work
000000697 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000697 980__ $$aTheses and Dissertations