000007051 001__ 7051 000007051 005__ 20231129124937.0 000007051 0247_ $$2DOI$$a10.6083/0c483k06z 000007051 037__ $$aETD 000007051 245__ $$aEvaluation of a novel microencapsulated orthodontic cement to prevent white spot lesions 000007051 260__ $$bOregon Health and Science University 000007051 269__ $$a2018 000007051 336__ $$aThesis 000007051 502__ $$bM.S. 000007051 502__ $$gOrthodontics 000007051 520__ $$aThe esthetic result of orthodontic therapy can be compromised by white spot lesion (WSL) development. WSLs are associated with increased bacterial accumulation exacerbated by orthodontic appliances and poor patient oral hygiene. One strategy to reduce WSL formation is to utilize orthodontic cements capable of releasing ions to inhibit bacterial growth and remineralize enamel. The Premier Dental Supply Company?s experimental cements incorporated with microcapsules containing a combination of Zn2+, PO43-, Ca2+, and F- were evaluated for their capability to minimize bacterial growth and the formation of WSLs and for their bond strength to enamel compared to a control. The experimental cements containing microencapsulated ions released significant levels of Zn2+, PO43-, Ca2+, and F- in an acidic aqueous solution (pH 5.15) over a 28-day period. The fluoride-containing formulation demonstrated a mild inhibition of bacterial growth. There were no significant differences in WSL formation on enamel for any of the cements. While there were no significant differences in the debonded adhesive remnants, the shear bond strengths were significantly lower for cements containing microcapsules, though they were still within the clinically-acceptable range. Future studies should focus on clinical capabilities of the cements and verify the adequacy of the bond strength. 000007051 540__ $$fCC BY 000007051 542__ $$fIn copyright - single owner 000007051 650__ $$aOrthodontic Brackets$$029521 000007051 650__ $$aOrthodontics$$023308 000007051 650__ $$aTooth Demineralization$$029606 000007051 650__ $$aDental Enamel$$017496 000007051 650__ $$aDental Cements$$017491 000007051 691__ $$aSchool of Dentistry$$041368 000007051 692__ $$aDepartment of Orthodontics$$041435 000007051 7001_ $$aYih, Jonathan 000007051 8564_ $$9a6a92940-3b99-4481-9f4b-cac09ad552bd$$s1312956$$uhttps://digitalcollections.ohsu.edu/record/7051/files/yih.Jonathan.2018.pdf 000007051 905__ $$a/rest/prod/0c/48/3k/06/0c483k06z 000007051 909CO $$ooai:digitalcollections.ohsu.edu:7051$$pstudent-work 000007051 980__ $$aTheses and Dissertations