000000712 001__ 712
000000712 005__ 20260120144837.0
000000712 0247_ $$2DOI$$a10.6083/M4M906NH
000000712 037__ $$aETD
000000712 245__ $$aRole of Axin1 scaffold protein in regulating the c-myc onocoprotein
000000712 260__ $$bOregon Health and Science University
000000712 269__ $$a2012
000000712 336__ $$aThesis
000000712 502__ $$bM.S.
000000712 502__ $$gCancer Biology (sunsetting)
000000712 520__ $$aThis thesis investigates Axin1’s role in regulating the c-Myc oncoprotein in leukemia and examines the contribution of Axin1 Exon 7 to c-Myc binding and transcriptional control. Increased Axin1 levels reduced c-Myc in U937 leukemia cells, which predominantly express a less effective Axin1 isoform. Sequencing of 26 patient samples revealed rare Axin1 mutations. Functional studies show Exon 7 contains a conserved domain critical for c-Myc regulation but dispensable for β-Catenin activity. These findings expand understanding of Axin1’s tumor suppressor function and provide tools to dissect its pathway-specific roles in cancer.
000000712 540__ $$fCC BY
000000712 542__ $$fIn copyright - single owner
000000712 650__ $$aNeoplasms$$022758
000000712 650__ $$aAxin Protein$$039753
000000712 650__ $$aProto-Oncogene Proteins c-myc$$029021
000000712 650__ $$aLeukemia$$021430
000000712 650__ $$aOncogene Proteins$$028466
000000712 6531_ $$acancer
000000712 691__ $$aSchool of Medicine$$041369
000000712 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000000712 7001_ $$aKrishnamoorthy, Arun$$uOregon Health and Science University$$041354
000000712 7201_ $$aSears, Rosalie$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000712 8564_ $$9c59469fc-f0ce-444b-8d29-c8e8757b6e26$$s2296792$$uhttps://digitalcollections.ohsu.edu/record/712/files/715_etd.pdf$$ePublic$$2fe91866876d8edb52e137c7004741773$$31
000000712 905__ $$a/rest/prod/r4/94/vk/22/r494vk22c
000000712 909CO $$ooai:digitalcollections.ohsu.edu:712$$pstudent-work
000000712 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000712 980__ $$aTheses and Dissertations