@article{ETD, recid = {713}, author = {Lee, Shin}, title = {Implications of neuropeptide Y induction in the dorsomedial hypothalamus for hyperphagia and obesity}, publisher = {Oregon Health and Science University}, school = {Ph.D.}, address = {2011}, number = {ETD}, abstract = {Obesity rates are rising, yet treatments remain limited due to incomplete understanding of energy homeostasis. Neuropeptide Y (NPY) neurons in the dorsomedial hypothalamus (DMH) have emerged as key regulators of feeding behavior, promoting energy intake over expenditure. This thesis examines DMH-NPY neurons during development, lactation, and diet-induced obesity using gene expression analysis, neuronal tracing, and characterization of leptin and CART interactions. Findings reveal distinct mechanisms driving DMH-NPY activation and hyperphagia, offering insights into hypothalamic adaptations that favor positive energy balance and contribute to obesity.}, url = {http://digitalcollections.ohsu.edu/record/713}, doi = {https://doi.org/10.6083/M4GH9FZP}, }