TY  - GEN
AB  - Obesity rates are rising, yet treatments remain limited due to incomplete understanding of energy homeostasis. Neuropeptide Y (NPY) neurons in the dorsomedial hypothalamus (DMH) have emerged as key regulators of feeding behavior, promoting energy intake over expenditure. This thesis examines DMH-NPY neurons during development, lactation, and diet-induced obesity using gene expression analysis, neuronal tracing, and characterization of leptin and CART interactions. Findings reveal distinct mechanisms driving DMH-NPY activation and hyperphagia, offering insights into hypothalamic adaptations that favor positive energy balance and contribute to obesity.
AD  - Oregon Health and Science University
AU  - Lee, Shin
DA  - 2011
DO  - 10.6083/M4GH9FZP
DO  - DOI
ED  - Grove, Kevin
ED  - Advisor
ED  - Mentor
ID  - 713
KW  - Neuropeptide Y
KW  - Body Weight Changes
KW  - Homeostasis
KW  - Eating
KW  - Body Weight
KW  - Hypothalamus
KW  - Thermogenesis
KW  - Obesity
L1  - https://digitalcollections.ohsu.edu/record/713/files/716_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/713/files/716_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/713/files/716_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/713/files/716_etd.pdf
N2  - Obesity rates are rising, yet treatments remain limited due to incomplete understanding of energy homeostasis. Neuropeptide Y (NPY) neurons in the dorsomedial hypothalamus (DMH) have emerged as key regulators of feeding behavior, promoting energy intake over expenditure. This thesis examines DMH-NPY neurons during development, lactation, and diet-induced obesity using gene expression analysis, neuronal tracing, and characterization of leptin and CART interactions. Findings reveal distinct mechanisms driving DMH-NPY activation and hyperphagia, offering insights into hypothalamic adaptations that favor positive energy balance and contribute to obesity.
PB  - Oregon Health and Science University
PY  - 2011
T1  - Implications of neuropeptide Y induction in the dorsomedial hypothalamus for hyperphagia and obesity
TI  - Implications of neuropeptide Y induction in the dorsomedial hypothalamus for hyperphagia and obesity
UR  - https://digitalcollections.ohsu.edu/record/713/files/716_etd.pdf
Y1  - 2011
ER  -