TY  - GEN
AB  - Inner ear hair cells are essential for hearing, balance, and acceleration, yet they do not regenerate in humans, making their maintenance critical for preventing age-related hearing loss. The molecular mechanisms underlying normal hair-cell function and recovery from damage remain poorly understood. This study characterizes energy metabolism in hair cells of chicken auditory and vestibular organs and examines cellular responses to hair-bundle tip link damage. Findings provide insight into metabolic processes and repair mechanisms that support hair-cell resilience, offering a foundation for strategies to preserve sensory function and mitigate hearing loss.
AD  - Oregon Health and Science University
AU  - Spinelli, Kateri
DA  - 2012
DO  - 10.6083/M4XG9P5Z
DO  - DOI
ED  - Gillespie, Peter
ED  - Advisor
ID  - 725
KW  - Glycolysis
KW  - Cochlea
KW  - Hearing Loss
KW  - Energy Metabolism
KW  - Chickens
KW  - Ear, Inner
KW  - Hair Cells, Auditory
KW  - Microscopy, Electron, Scanning
KW  - calcium imaging
L1  - https://digitalcollections.ohsu.edu/record/725/files/728_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/725/files/728_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/725/files/728_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/725/files/728_etd.pdf
N2  - Inner ear hair cells are essential for hearing, balance, and acceleration, yet they do not regenerate in humans, making their maintenance critical for preventing age-related hearing loss. The molecular mechanisms underlying normal hair-cell function and recovery from damage remain poorly understood. This study characterizes energy metabolism in hair cells of chicken auditory and vestibular organs and examines cellular responses to hair-bundle tip link damage. Findings provide insight into metabolic processes and repair mechanisms that support hair-cell resilience, offering a foundation for strategies to preserve sensory function and mitigate hearing loss.
PB  - Oregon Health and Science University
PY  - 2012
T1  - Molecular characterization of hair cell metabolism and tip link damage
TI  - Molecular characterization of hair cell metabolism and tip link damage
UR  - https://digitalcollections.ohsu.edu/record/725/files/728_etd.pdf
Y1  - 2012
ER  -