000000725 001__ 725
000000725 005__ 20260120144838.0
000000725 0247_ $$2DOI$$a10.6083/M4XG9P5Z
000000725 037__ $$aETD
000000725 245__ $$aMolecular characterization of hair cell metabolism and tip link damage
000000725 260__ $$bOregon Health and Science University
000000725 269__ $$a2012
000000725 336__ $$aDissertation
000000725 502__ $$bPh.D.
000000725 502__ $$gNeuroscience
000000725 520__ $$aInner ear hair cells are essential for hearing, balance, and acceleration, yet they do not regenerate in humans, making their maintenance critical for preventing age-related hearing loss. The molecular mechanisms underlying normal hair-cell function and recovery from damage remain poorly understood. This study characterizes energy metabolism in hair cells of chicken auditory and vestibular organs and examines cellular responses to hair-bundle tip link damage. Findings provide insight into metabolic processes and repair mechanisms that support hair-cell resilience, offering a foundation for strategies to preserve sensory function and mitigate hearing loss.
000000725 540__ $$fCC BY
000000725 542__ $$fIn copyright - single owner
000000725 650__ $$aGlycolysis$$019653
000000725 650__ $$aCochlea$$016848
000000725 650__ $$aHearing Loss$$034564
000000725 650__ $$aEnergy Metabolism$$018446
000000725 650__ $$aChickens$$016459
000000725 650__ $$aEar, Inner$$021268
000000725 650__ $$aHair Cells, Auditory$$019810
000000725 650__ $$aMicroscopy, Electron, Scanning$$022284
000000725 6531_ $$acalcium imaging
000000725 691__ $$aSchool of Medicine$$041369
000000725 692__ $$aVollum Institute$$041509
000000725 7001_ $$aSpinelli, Kateri$$uOregon Health and Science University$$041354
000000725 7201_ $$aGillespie, Peter$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000725 8564_ $$9e3c78be3-fb09-4d91-a8df-8741acc4cbbe$$s4556180$$uhttps://digitalcollections.ohsu.edu/record/725/files/728_etd.pdf$$ePublic$$21ff4840cb629a3ca7ab3372f8479f974$$31
000000725 905__ $$a/rest/prod/gx/41/mh/89/gx41mh89h
000000725 909CO $$ooai:digitalcollections.ohsu.edu:725$$pstudent-work
000000725 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000725 980__ $$aTheses and Dissertations