@article{ETD,
      recid = {729},
      author = {Buels, Kalmia},
      title = {Tiotropium inhibits increases in nerve-associated  eosinophils following antigen challenge and prevents airway  hyperreactivity in a guinea pig model of asthma},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2011},
      number = {ETD},
      abstract = {Parasympathetic nerves strongly regulate airway tone, and  in allergic asthma, excess acetylcholine release  contributes to airway hyperresponsiveness linked to  nerve‑associated eosinophils. This work shows that blocking  M3 muscarinic receptors with tiotropium prevents  hyperresponsiveness in guinea pigs by reducing eosinophilic  inflammation rather than inhibiting bronchoconstriction.  Neurons can produce CCR3 chemokines in vitro, but in vivo  eosinophil recruitment appears driven mainly by  non‑neuronal cells. These findings suggest that M3  antagonists may reduce asthma exacerbations through  anti‑inflammatory effects, particularly by limiting  eosinophil interactions with airway nerves.},
      url = {http://digitalcollections.ohsu.edu/record/729},
      doi = {https://doi.org/10.6083/M4DJ5CMK},
}