TY  - GEN
AB  - Parasympathetic nerves strongly regulate airway tone, and in allergic asthma, excess acetylcholine release contributes to airway hyperresponsiveness linked to nerve‑associated eosinophils. This work shows that blocking M3 muscarinic receptors with tiotropium prevents hyperresponsiveness in guinea pigs by reducing eosinophilic inflammation rather than inhibiting bronchoconstriction. Neurons can produce CCR3 chemokines in vitro, but in vivo eosinophil recruitment appears driven mainly by non‑neuronal cells. These findings suggest that M3 antagonists may reduce asthma exacerbations through anti‑inflammatory effects, particularly by limiting eosinophil interactions with airway nerves.
AD  - Oregon Health and Science University
AU  - Buels, Kalmia
DA  - 2011
DO  - 10.6083/M4DJ5CMK
DO  - DOI
ED  - Fryer, Allison
ED  - Mentor
ID  - 729
KW  - Scopolamine Derivatives
KW  - Chemokines
KW  - Vagus Nerve
KW  - Cholinergic Antagonists
KW  - Eosinophils
KW  - Asthma
KW  - Receptors, Muscarinic
KW  - Parasympatholytics
L1  - https://digitalcollections.ohsu.edu/record/729/files/732_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/729/files/732_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/729/files/732_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/729/files/732_etd.pdf
N2  - Parasympathetic nerves strongly regulate airway tone, and in allergic asthma, excess acetylcholine release contributes to airway hyperresponsiveness linked to nerve‑associated eosinophils. This work shows that blocking M3 muscarinic receptors with tiotropium prevents hyperresponsiveness in guinea pigs by reducing eosinophilic inflammation rather than inhibiting bronchoconstriction. Neurons can produce CCR3 chemokines in vitro, but in vivo eosinophil recruitment appears driven mainly by non‑neuronal cells. These findings suggest that M3 antagonists may reduce asthma exacerbations through anti‑inflammatory effects, particularly by limiting eosinophil interactions with airway nerves.
PB  - Oregon Health and Science University
PY  - 2011
T1  - Tiotropium inhibits increases in nerve-associated eosinophils following antigen challenge and prevents airway hyperreactivity in a guinea pig model of asthma
TI  - Tiotropium inhibits increases in nerve-associated eosinophils following antigen challenge and prevents airway hyperreactivity in a guinea pig model of asthma
UR  - https://digitalcollections.ohsu.edu/record/729/files/732_etd.pdf
Y1  - 2011
ER  -