000000729 001__ 729
000000729 005__ 20260410124450.0
000000729 0247_ $$2DOI$$a10.6083/M4DJ5CMK
000000729 037__ $$aETD
000000729 245__ $$aTiotropium inhibits increases in nerve-associated eosinophils following antigen challenge and prevents airway hyperreactivity in a guinea pig model of asthma
000000729 260__ $$bOregon Health and Science University
000000729 269__ $$a2011
000000729 336__ $$aDissertation
000000729 502__ $$bPh.D.
000000729 502__ $$gPhysiology &amp; Pharmacology (sunsetting)
000000729 520__ $$aParasympathetic nerves strongly regulate airway tone, and in allergic asthma, excess acetylcholine release contributes to airway hyperresponsiveness linked to nerve‑associated eosinophils. This work shows that blocking M3 muscarinic receptors with tiotropium prevents hyperresponsiveness in guinea pigs by reducing eosinophilic inflammation rather than inhibiting bronchoconstriction. Neurons can produce CCR3 chemokines in vitro, but in vivo eosinophil recruitment appears driven mainly by non‑neuronal cells. These findings suggest that M3 antagonists may reduce asthma exacerbations through anti‑inflammatory effects, particularly by limiting eosinophil interactions with airway nerves.
000000729 540__ $$fCC BY
000000729 542__ $$fIn copyright - single owner
000000729 650__ $$aScopolamine Derivatives$$025800
000000729 650__ $$aChemokines$$031204
000000729 650__ $$aVagus Nerve$$027710
000000729 650__ $$aCholinergic Antagonists$$031005
000000729 650__ $$aEosinophils$$018511
000000729 650__ $$aAsthma$$015168
000000729 650__ $$aReceptors, Muscarinic$$025211
000000729 650__ $$aParasympatholytics$$023594
000000729 691__ $$aSchool of Medicine$$041369
000000729 692__ $$aDepartment of Physiology and Pharmacology$$041442
000000729 7001_ $$aBuels, Kalmia$$uOregon Health and Science University$$041354
000000729 7201_ $$aFryer, Allison$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000729 8564_ $$99186c196-b298-4231-8159-64a6d1bc5872$$s5280726$$uhttps://digitalcollections.ohsu.edu/record/729/files/732_etd.pdf$$ePublic$$27bf7e19e78344ff012cd1d5e42e957dc$$31
000000729 901__ $$a&lt;p&gt;These documents are archival records. They are retained for historical reference only. &lt;/p&gt;&lt;p&gt;&lt;b&gt;Need an accessible version? Use the ‘Get Accessible Copy’ link above.&lt;/b&gt;&lt;/p&gt;
000000729 905__ $$a/rest/prod/rv/04/2t/09/rv042t09t
000000729 909CO $$ooai:digitalcollections.ohsu.edu:729$$pstudent-work
000000729 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000729 980__ $$aTheses and Dissertations