000000735 001__ 735
000000735 005__ 20260120144838.0
000000735 0247_ $$2DOI$$a10.6083/M4N29TZ9
000000735 037__ $$aETD
000000735 245__ $$aInvestigating the biosynthetic and metabolic pathways of 3-Iodothyronamine
000000735 260__ $$bOregon Health and Science University
000000735 269__ $$a2012
000000735 336__ $$aDissertation
000000735 502__ $$bPh.D.
000000735 502__ $$gPhysiology & Pharmacology (sunsetting)
000000735 520__ $$a3-Iodothyronamine (T1AM), an endogenous thyroid hormone derivative, exhibits pharmacological effects opposite to thyroid hormone, including hypothermia, reduced cardiac function, and altered fuel utilization. Structural and metabolic similarities suggest T1AM may originate from thyroid hormone. Using isotope-labeled thyroid hormone and hypothyroid mice, LC-MS/MS analysis showed T1AM biosynthesis depends on thyroid gland function but is not derived from extrathyroidal metabolism. Following T1AM injection, extensive metabolism was observed, identifying novel serum metabolites—N-acetyl-T1AM and T1AM-glucuronide—along with sulfation and oxidative deamination. Several metabolites exceeded parent compound levels, indicating metabolism regulates T1AM distribution and action, paralleling thyroid hormone pathways.
000000735 540__ $$fCC BY
000000735 542__ $$fIn copyright - single owner
000000735 650__ $$aThyronines$$027077
000000735 650__ $$aMetabolic Networks and Pathways$$037648
000000735 650__ $$aBiosynthetic Pathways$$037651
000000735 650__ $$aMetabolism$$022101
000000735 650__ $$aMass Spectrometry$$026224
000000735 650__ $$aGlucuronides$$032634
000000735 650__ $$aMice$$036842
000000735 650__ $$aThyroid Hormones$$027070
000000735 650__ $$a3-iodothyronamine
000000735 691__ $$aSchool of Medicine$$041369
000000735 692__ $$aDepartment of Physiology and Pharmacology$$041442
000000735 7001_ $$aHackenmueller, Sarah$$uOregon Health and Science University$$041354
000000735 7201_ $$aScanlan, Thomas$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000735 8564_ $$97f5c3d8a-2fcd-4796-bee4-a2a523e2e229$$s13419942$$uhttps://digitalcollections.ohsu.edu/record/735/files/738_etd.pdf$$ePublic$$27e0b1dbf4fd639eecfdda592907e2e31$$31
000000735 905__ $$a/rest/prod/mg/74/qm/12/mg74qm120
000000735 909CO $$ooai:digitalcollections.ohsu.edu:735$$pstudent-work
000000735 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000735 980__ $$aTheses and Dissertations