000000739 001__ 739
000000739 005__ 20260410124451.0
000000739 0247_ $$2DOI$$a10.6083/M4445JG7
000000739 037__ $$aETD
000000739 245__ $$aThe role of the TtpC protein in energy transduction in the TonB2 systems of pathogenic vibrois
000000739 260__ $$bOregon Health and Science University
000000739 269__ $$a2011
000000739 336__ $$aDissertation
000000739 502__ $$bPh.D.
000000739 502__ $$gMolecular Microbiology &amp; Immunology (sunsetting)
000000739 520__ $$aIron acquisition is essential for bacterial survival, and Gram‑negative species rely on the TonB‑ExbB‑ExbD system to transfer energy from the inner membrane to outer‑membrane iron‑siderophore transporters. Unlike E. coli, Vibrio species possess multiple TonB systems that include an additional protein, TtpC, which is required for energy transduction and iron uptake. TtpC shares a conserved SxxxH motif—absent in Vibrio TonB2 but essential for Fe‑ferrichrome transport—supporting its role as the primary energy‑transducing component. These findings reveal a unique four‑protein TonB2 system in Vibrio, indicating a more complex, specialized mechanism of energy transduction used by marine bacteria.
000000739 540__ $$fCC BY
000000739 542__ $$fIn copyright - single owner
000000739 650__ $$aBacterial Proteins$$015330
000000739 650__ $$aVibrio cholerae$$027808
000000739 650__ $$aSiderophores$$029823
000000739 650__ $$aTransduction, Genetic$$027259
000000739 6531_ $$avibrio anguillarum
000000739 691__ $$aSchool of Medicine$$041369
000000739 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000739 7001_ $$aKuehl, Carole$$uOregon Health and Science University$$041354
000000739 7201_ $$aCrosa, Jorge$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000739 8564_ $$9cde4dc9a-b98e-480f-bf7e-b6a093833c41$$s4624795$$uhttps://digitalcollections.ohsu.edu/record/739/files/742_etd.pdf$$ePublic$$220fad0316b8b54d33c3023411b1df119$$31
000000739 901__ $$a&lt;p&gt;These documents are archival records. They are retained for historical reference only. &lt;/p&gt;&lt;p&gt;&lt;b&gt;Need an accessible version? Use the ‘Get Accessible Copy’ link above.&lt;/b&gt;&lt;/p&gt;
000000739 905__ $$a/rest/prod/c2/47/ds/13/c247ds13s
000000739 909CO $$ooai:digitalcollections.ohsu.edu:739$$pstudent-work
000000739 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000739 980__ $$aTheses and Dissertations