000000741 001__ 741
000000741 005__ 20251216111113.0
000000741 0247_ $$2DOI$$a10.6083/M4VM4992
000000741 037__ $$aETD
000000741 245__ $$aEffects of elevated testosterone levels on reproductive neuroendocrine function and behavior in female rhesus macaques (macaca mulatta)
000000741 260__ $$bOregon Health and Science University
000000741 269__ $$a2012
000000741 336__ $$aDissertation
000000741 502__ $$bPh.D.
000000741 502__ $$gBehavioral & Systems Neuroscience
000000741 520__ $$aHyperandrogenemia (HA) is linked to polycystic ovary syndrome (PCOS), a disorder characterized by elevated androgens, neuroendocrine changes, and metabolic dysfunction. We tested whether chronic low-dose testosterone (T) exposure in female monkeys induces PCOS-like traits. T treatment increased LH pulse frequency and GnRH responsiveness but did not initially alter ovarian or metabolic function. After adding a Western-style diet, all animals developed polycystic ovarian morphology, and T-treated monkeys showed reduced insulin sensitivity. Behaviorally, T-treated monkeys exhibited less inhibition, correlating with greater weight gain. These findings suggest that HA combined with diet promotes neuroendocrine, ovarian, metabolic, and behavioral features of PCOS.
000000741 540__ $$fCC BY
000000741 542__ $$fIn copyright - single owner
000000741 650__ $$aAnxiety$$014946
000000741 650__ $$aObesity$$023118
000000741 650__ $$aPolycystic Ovary Syndrome$$024369
000000741 650__ $$aAggression$$014357
000000741 650__ $$aHyperandrogenism$$030088
000000741 650__ $$aTestosterone$$026859
000000741 650__ $$aDiet$$017776
000000741 650__ $$aMacaca mulatta$$021724
000000741 6531_ $$aaggressiveness
000000741 691__ $$aSchool of Medicine$$041369
000000741 692__ $$aDepartment of Behavioral Neuroscience$$041394
000000741 7001_ $$aMcGee, Whitney$$uOregon Health and Science University$$041354
000000741 7201_ $$aCameron, Judy$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000741 8564_ $$936ca8f16-4526-40be-a575-c1287fed1168$$s1554641$$uhttps://digitalcollections.ohsu.edu/record/741/files/744_etd.pdf$$ePublic$$2d2c5e6b968a5e6b3d73c3b14e7b5ab0d$$31
000000741 905__ $$a/rest/prod/2z/10/wq/22/2z10wq22z
000000741 909CO $$ooai:digitalcollections.ohsu.edu:741$$pstudent-work
000000741 980__ $$aTheses and Dissertations