000000742 001__ 742
000000742 005__ 20260120144838.0
000000742 0247_ $$2DOI$$a10.6083/M4QV3JJW
000000742 037__ $$aETD
000000742 245__ $$aStudies on poly-ICLC treatment as a potent neuroprotective therapy against ischemic brain injury
000000742 260__ $$bOregon Health and Science University
000000742 269__ $$a2011
000000742 336__ $$aDissertation
000000742 502__ $$bPh.D.
000000742 502__ $$gNeuroscience
000000742 520__ $$aPreconditioning induces ischemic tolerance by reprogramming the brain’s response to injury, reducing harmful inflammation and enhancing neuroprotective pathways. Seeking clinically applicable stimuli, we identified poly‑IC as a potent preconditioning agent that provides robust protection in vitro and in vivo across multiple murine ischemia‑reperfusion models, with minimal systemic inflammation. Poly‑ICLC activates interferon‑related genes shared with other preconditioning stimuli, and its protection requires IRF7 and type I interferon signaling. Using TLR9 knockout bone‑marrow chimeras, we found that CpG‑induced protection requires TLR9 expression on both hematopoietic and parenchymal cells. These findings highlight poly‑IC/poly‑ICLC as promising prophylactic therapies for ischemic injury.
000000742 540__ $$fCC BY
000000742 542__ $$fIn copyright - single owner
000000742 650__ $$aIschemic Preconditioning$$031418
000000742 650__ $$aInterferon Type I$$020912
000000742 650__ $$aOligodeoxyribonucleotides$$023185
000000742 650__ $$aPoly I-C$$024356
000000742 650__ $$aStroke$$032460
000000742 650__ $$aCerebrovascular Disorders$$016383
000000742 650__ $$apoly ICLC
000000742 650__ $$aToll-Like Receptor 9$$036761
000000742 6531_ $$acpg-oligonucleotide
000000742 691__ $$aSchool of Medicine$$041369
000000742 692__ $$aVollum Institute$$041509
000000742 7001_ $$aBruestle Packard, Amy$$uOregon Health and Science University$$041354
000000742 7201_ $$aStenzel-Poore, Mary$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000742 8564_ $$9c50f9834-2416-42bc-b348-f9b07142e3b0$$s1516227$$uhttps://digitalcollections.ohsu.edu/record/742/files/745_etd.pdf$$ePublic$$260e6b965355263fe2a4c9eca5929f65a$$31
000000742 905__ $$a/rest/prod/st/74/cq/45/st74cq459
000000742 909CO $$ooai:digitalcollections.ohsu.edu:742$$pstudent-work
000000742 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000742 980__ $$aTheses and Dissertations