000000745 001__ 745
000000745 005__ 20260120144838.0
000000745 0247_ $$2DOI$$a10.6083/M4BK19CT
000000745 037__ $$aETD
000000745 245__ $$aIn vivo and in vitro characterization of the p66ShcA inactivation: axonal and neuronal protection in the context of multiple sclerosis
000000745 260__ $$bOregon Health and Science University
000000745 269__ $$a2011
000000745 336__ $$aDissertation
000000745 502__ $$bPh.D.
000000745 502__ $$gNeuroscience
000000745 520__ $$aMultiple sclerosis (MS) involves both inflammation and neurodegeneration, with mitochondrial dysfunction and oxidative stress playing key roles. Using the EAE mouse model, we investigated p66ShcA (p66), a redox enzyme that promotes mitochondrial ROS production. p66-knockout mice exhibited reduced clinical severity and axonal damage despite similar inflammation compared to wild-type mice. Neuronal cultures from p66-KO mice showed greater resistance to oxidative stress and preserved mitochondrial integrity. These findings implicate p66 in pathways leading to mitochondrial permeability transition pore activation and neurodegeneration, suggesting p66 inhibition as a potential therapeutic strategy for MS.
000000745 540__ $$fCC BY
000000745 542__ $$fIn copyright - single owner
000000745 650__ $$aMitochondria$$022348
000000745 650__ $$aShc Signaling Adaptor Proteins$$038462
000000745 650__ $$aReactive Oxygen Species$$029926
000000745 650__ $$aMultiple Sclerosis$$022506
000000745 650__ $$aMitochondrial Diseases$$033486
000000745 650__ $$aMice, Knockout$$030736
000000745 650__ $$aMice$$036842
000000745 650__ $$aInflammation$$020800
000000745 650__ $$aMitochondrial Permeability Transition Pore$$013351
000000745 6531_ $$aactive oxygen
000000745 6531_ $$aaxonal degeneration
000000745 6531_ $$ap66shca
000000745 691__ $$aSchool of Medicine$$041369
000000745 692__ $$aVollum Institute$$041509
000000745 7001_ $$aSu, Kimmy$$uOregon Health and Science University$$041354
000000745 7201_ $$aBourdette, Dennis$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000745 7201_ $$aForte, Michael$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000745 8564_ $$98501f051-641b-41e6-bfc1-2f6e00496d54$$s5266701$$uhttps://digitalcollections.ohsu.edu/record/745/files/748_etd.pdf$$ePublic$$2762c0298a4bfd95cfc322d3078f4543d$$31
000000745 905__ $$a/rest/prod/js/95/6f/81/js956f81p
000000745 909CO $$ooai:digitalcollections.ohsu.edu:745$$pstudent-work
000000745 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000745 980__ $$aTheses and Dissertations