000007450 001__ 7450
000007450 005__ 20231214104151.0
000007450 0247_ $$2DOI$$a10.6083/bz60cw871
000007450 037__ $$aETD
000007450 245__ $$aGenomic instability of solid tumors and clinical applications
000007450 260__ $$bOregon Health and Science University
000007450 260__ $$bOregon Health and Science University
000007450 269__ $$a2018
000007450 336__ $$aThesis
000007450 502__ $$bM.S.
000007450 520__ $$aChromosomal abnormalities caused by genomic instability are a consistent feature of
cancer cells. However, the mechanisms that lead to genomic instability and its role in cancer progression, and ultimately clinical outcome, are not well understood. Advances in whole genome sequencing and other high-throughput molecular techniques have vastly improved our ability to characterize cancers. Researchers have begun to measure genomic/chromosomal instability (GI/CIN) by using multiple data types, including copy number, gene expression, and somatic mutations. These measures of instability have been associated with various clinical outcomes, but results have been inconsistent. Several methods for creating summary measures of CIN have been published, but there is no consensus about the best method. Additionally, it is unclear whether any one method is appropriate for all cancer types. Current methods also do not take advantage of information about specific cytogenetic abnormalities that are recurrent in specific cancer types. Given the potential clinical value of CIN as a predictor of cancer progression or treatment response, there is a critical need to better understand how best to summarize measures of CIN.
000007450 540__ $$fCC BY
000007450 542__ $$fIn copyright - single owner
000007450 650__ $$aGenomic Instability$$035232
000007450 650__ $$aSurvival$$026674
000007450 650__ $$aChromosome Aberrations$$016677
000007450 6531_ $$acancer
000007450 6531_ $$atumors
000007450 691__ $$aSchool of Medicine$$041369
000007450 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000007450 7001_ $$aChoonoo, Gabrielle$$uOregon Health and Science University$$041354
000007450 8564_ $$9a9321b3f-cf7a-4b88-bab1-58594cd77a05$$s7298018$$uhttps://digitalcollections.ohsu.edu/record/7450/files/Choonoo_Thesis_Document_Final.pdf
000007450 905__ $$a/rest/prod/bz/60/cw/87/bz60cw871
000007450 909CO $$ooai:digitalcollections.ohsu.edu:7450$$pstudent-work
000007450 980__ $$aBiomedical Informatics