000000746 001__ 746
000000746 005__ 20251216110206.0
000000746 0247_ $$2DOI$$a10.6083/M46W9828
000000746 037__ $$aETD
000000746 245__ $$aDynamic lateral feedback inhibition in the retina
000000746 260__ $$bOregon Health and Science University
000000746 269__ $$a2012
000000746 336__ $$aDissertation
000000746 502__ $$bPh.D.
000000746 502__ $$gNeuroscience
000000746 520__ $$aWe recorded light-evoked lateral inhibitory postsynaptic currents (L-IPSCs) from ON-type mixed rod/cone bipolar cell terminals in goldfish retina to characterize their timing, mechanisms, and plasticity. L-IPSCs showed ON (∼50 ms) and OFF (100–150 ms) components mediated by GABA_A/GABA_C receptors and AMPA/NMDA signaling. ON inputs combined rod and cone signals; OFF inputs were cone-driven and relied on spiking amacrine cells. Paired-flash protocols revealed short-term depression for ON and depression-to-facilitation for OFF responses. Ascorbic acid enhanced GABAergic currents, suggesting a modulatory role in plasticity. These findings reveal distinct, dynamic inhibitory pathways regulating glutamate release at bipolar terminals.
000000746 540__ $$fCC BY
000000746 542__ $$fIn copyright - single owner
000000746 650__ $$aNeural Inhibition$$022818
000000746 650__ $$aGABA-A Receptor Agonists$$039349
000000746 650__ $$aPresynaptic Terminals$$030195
000000746 650__ $$aRetinal Ganglion Cells$$025392
000000746 650__ $$aPhysiology$$024123
000000746 650__ $$aRetinal Bipolar Cells$$036781
000000746 650__ $$aPharmacology$$023909
000000746 650__ $$aAscorbic Acid$$015129
000000746 650__ $$aNeuronal Plasticity$$022857
000000746 650__ $$aGABA Agonists$$031070
000000746 650__ $$aReceptors, Presynaptic$$030136
000000746 650__ $$aneuroplasticity
000000746 6531_ $$avitamin c
000000746 691__ $$aSchool of Medicine$$041369
000000746 692__ $$aVollum Institute$$041509
000000746 7001_ $$aVickers, Evan$$uOregon Health and Science University$$041354
000000746 7201_ $$avon Gersdorff, Henrique$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000746 8564_ $$9961c811c-bcb6-4738-ac9e-6efb327fb6dc$$s2747972$$uhttps://digitalcollections.ohsu.edu/record/746/files/749_etd.pdf$$ePublic$$2615ee0f15263a05906331f0abce33f7e$$31
000000746 905__ $$a/rest/prod/4q/77/fr/38/4q77fr380
000000746 909CO $$ooai:digitalcollections.ohsu.edu:746$$pstudent-work
000000746 980__ $$aTheses and Dissertations