000007461 001__ 7461 000007461 005__ 20250424233233.0 000007461 0247_ $$2DOI$$a10.6083/vt150j93m 000007461 037__ $$aETD 000007461 245__ $$aSynaptic transmission and electrical resonance in early auditory processing 000007461 260__ $$bOregon Health and Science University 000007461 269__ $$a2019 000007461 336__ $$aDissertation 000007461 502__ $$bPh.D. 000007461 520__ $$aThis dissertation investigates two unique phenomena, neurotransmitter co-release and neural oscillations, in early auditory regions where they have not been observed before. Co-release and oscillations are common processes in other brain regions, where they are thought to expand the computational capacity of local circuits. We investigated co-release of two inhibitory neurotransmitters in the inferior colliculus, the midbrain hub for auditory processing. We also established the presence of slow oscillations in the principal neurons of the dorsal cochlear nucleus (DCN), a key brainstem nucleus that integrates auditory input from the ear with multisensory information. Both lines of research utilized patch-clamp electrophysiological recordings from in vitro slices of mouse brainstem and midbrain. This dissertation reveals new mechanisms for how auditory information is processed by local brainstem and midbrain circuits. 000007461 540__ $$fCC BY 000007461 542__ $$fIn copyright - single owner 000007461 650__ $$aInferior Colliculi$$020796 000007461 650__ $$aNeurons$$022858 000007461 650__ $$aMice$$036842 000007461 650__ $$aReticular Formation$$025382 000007461 650__ $$aGlycine$$019632 000007461 650__ $$aMembrane Potentials$$022008 000007461 6531_ $$abrainstem 000007461 691__ $$aSchool of Medicine$$041369 000007461 692__ $$aVollum Institute$$041509 000007461 7001_ $$aMoore, Lucille 000007461 8564_ $$98e3fe82d-55ad-4e8c-be79-f3faacfc1e22$$s3249256$$uhttps://digitalcollections.ohsu.edu/record/7461/files/moore.lucille.2019.pdf$$ePublic$$26b914893694250308538b3f0d762f10f$$31 000007461 905__ $$a/rest/prod/vt/15/0j/93/vt150j93m 000007461 909CO $$ooai:digitalcollections.ohsu.edu:7461$$pstudent-work 000007461 980__ $$aTheses and Dissertations