000007461 001__ 7461
000007461 005__ 20231129124940.0
000007461 0247_ $$2DOI$$a10.6083/vt150j93m
000007461 037__ $$aETD
000007461 245__ $$aSynaptic transmission and electrical resonance in early auditory processing
000007461 260__ $$bOregon Health and Science University
000007461 269__ $$a2019
000007461 336__ $$aDissertation
000007461 502__ $$bPh.D.
000007461 520__ $$aThis dissertation investigates two unique phenomena, neurotransmitter co-release and neural oscillations, in early auditory regions where they have not been observed before. Co-release and oscillations are common processes in other brain regions, where they are thought to expand the computational capacity of local circuits. We investigated co-release of two inhibitory neurotransmitters in the inferior colliculus, the midbrain hub for auditory processing. We also established the presence of slow oscillations in the principal neurons of the dorsal cochlear nucleus (DCN), a key brainstem nucleus that integrates auditory input from the ear with multisensory information. Both lines of research utilized patch-clamp electrophysiological recordings from in vitro slices of mouse brainstem and midbrain. This dissertation reveals new mechanisms for how auditory information is processed by local brainstem and midbrain circuits.
000007461 540__ $$fCC BY
000007461 542__ $$fIn copyright - single owner
000007461 650__ $$aInferior Colliculi$$020796
000007461 650__ $$aNeurons$$022858
000007461 650__ $$aMice$$036842
000007461 650__ $$aReticular Formation$$025382
000007461 650__ $$aGlycine$$019632
000007461 650__ $$aMembrane Potentials$$022008
000007461 6531_ $$abrainstem
000007461 691__ $$aSchool of Medicine$$041369
000007461 692__ $$aVollum Institute$$041509
000007461 7001_ $$aMoore, Lucille
000007461 8564_ $$98e3fe82d-55ad-4e8c-be79-f3faacfc1e22$$s3249256$$uhttps://digitalcollections.ohsu.edu/record/7461/files/moore.lucille.2019.pdf
000007461 905__ $$a/rest/prod/vt/15/0j/93/vt150j93m
000007461 909CO $$ooai:digitalcollections.ohsu.edu:7461$$pstudent-work
000007461 980__ $$aTheses and Dissertations