@article{ETD,
      recid = {747},
      author = {Wang, Zhongya},
      title = {A newly designed AAV-rDNA vector for persistent therapy in  genetic liver diseases},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2012},
      number = {ETD},
      abstract = {Adeno-associated virus (AAV) is widely used in gene  therapy but has limited integration, reducing long-term  transgene expression. We engineered an AAV-rDNA vector to  enhance integration and tested it in HT1 and hemophilia B  mouse models. AAV-rDNA achieved 10–30 times higher  integration and functional expression than control vectors,  rescuing disease at much lower doses and restoring normal  liver function. Integration was site-specific within rDNA  repeats, confirmed by sequencing. These findings  demonstrate that AAV-rDNA vectors enable efficient, stable  gene expression and represent a promising approach for  treating genetic disorders requiring persistent  correction.},
      url = {http://digitalcollections.ohsu.edu/record/747},
      doi = {https://doi.org/10.6083/M4348HC9},
}