000007481 001__ 7481
000007481 005__ 20231129124941.0
000007481 0247_ $$2DOI$$a10.6083/zc77sq70d
000007481 037__ $$aETD
000007481 245__ $$aThe role of the platelet-endothelium interface and regulation of platelet function
000007481 260__ $$bOregon Health and Science University
000007481 269__ $$a2019
000007481 336__ $$aThesis
000007481 502__ $$bM.S.
000007481 520__ $$aPlatelets are the first responders to vascular injury, playing a critical role in the formation of a hemostatic plug to stop and prevent blood loss. This process requires a complex sequence of mechanisms that is initiated by exposed extracellular matrix and damaged endothelial cells and results in platelet adhesion, activation, and aggregation at the site of vascular injury. Platelet binding of extracellular matrix proteins is required for formation of platelet aggregates, and their interaction may have significant impact on platelet function in inflammation and thrombosis. The following studies identify the role of the extracellular matrix protein nidogen-1 in adhesion and activation of platelets and provide rationale for the development of microfluidic platforms for investigation of the platelet endothelium interface.
000007481 650__ $$aPlatelet Activation$$028486
000007481 650__ $$aExtracellular Matrix Proteins$$029067
000007481 650__ $$aMicrofluidics$$035383
000007481 650__ $$aBlood Platelets$$015667
000007481 650__ $$aEndothelial Cells$$035222
000007481 6531_ $$anidogen-1
000007481 691__ $$aSchool of Medicine$$041369
000007481 692__ $$aDepartment of Biomedical Engineering$$041397
000007481 7001_ $$aSallee, Daniel
000007481 8564_ $$9ab3ae46f-1ea3-4be7-bbf2-882fd027f4a6$$s2164061$$uhttps://digitalcollections.ohsu.edu/record/7481/files/daniel.sallee.2019.pdf
000007481 905__ $$a/rest/prod/zc/77/sq/70/zc77sq70d
000007481 909CO $$ooai:digitalcollections.ohsu.edu:7481$$pstudent-work
000007481 980__ $$aTheses and Dissertations