TY  - GEN
N2  - Poly-ADP-ribose-polymerases (PARPs) are a family of 17 post translationally modifying enzymes in humans that catalyze the transfer of ADP-ribose from nicotinamide adenine dinucleotide (NAD+) onto target amino acids and nucleotides. PARPs can append long dendritic chains of ADP-ribose (poly-ADP-ribosylation, or PARylation) or monomers of ADP-ribose targets (mono-ADP ribosylation, or MARylation) to their). While the majority of the PARPs catalyze MARylation, there has been surprisingly little attention given to these enzymes or modification the last ten years. Even now, as evidence of the MARylating PARPs importance in basic biology and human diseases masses, very little is known about the function, targets, or biological mechanisms of these PARPs. Conversely, the PARylating PARPs are well understood.
DO  - 10.6083/xw42n845p
DO  - DOI
AB  - Poly-ADP-ribose-polymerases (PARPs) are a family of 17 post translationally modifying enzymes in humans that catalyze the transfer of ADP-ribose from nicotinamide adenine dinucleotide (NAD+) onto target amino acids and nucleotides. PARPs can append long dendritic chains of ADP-ribose (poly-ADP-ribosylation, or PARylation) or monomers of ADP-ribose targets (mono-ADP ribosylation, or MARylation) to their). While the majority of the PARPs catalyze MARylation, there has been surprisingly little attention given to these enzymes or modification the last ten years. Even now, as evidence of the MARylating PARPs importance in basic biology and human diseases masses, very little is known about the function, targets, or biological mechanisms of these PARPs. Conversely, the PARylating PARPs are well understood.
T1  - Towards selective poly-ADP-ribose polymerase inhibitors
DA  - 2019
AU  - Kirby, Ilsa
L1  - https://digitalcollections.ohsu.edu/record/7482/files/ilsa.kirby.2019.pdf
PB  - Oregon Health and Science University
PY  - 2019
ID  - 7482
L4  - https://digitalcollections.ohsu.edu/record/7482/files/ilsa.kirby.2019.pdf
KW  - Drug Design
KW  - Dihydrouracil Dehydrogenase (NAD+)
KW  - Poly(ADP-ribose) Polymerase Inhibitors
KW  - post-translational modification
KW  - posttranslational protein processing
TI  - Towards selective poly-ADP-ribose polymerase inhibitors
Y1  - 2019
L2  - https://digitalcollections.ohsu.edu/record/7482/files/ilsa.kirby.2019.pdf
LK  - https://digitalcollections.ohsu.edu/record/7482/files/ilsa.kirby.2019.pdf
UR  - https://digitalcollections.ohsu.edu/record/7482/files/ilsa.kirby.2019.pdf
ER  -