000007484 001__ 7484
000007484 005__ 20231129124940.0
000007484 0247_ $$2DOI$$a10.6083/6969z130f
000007484 037__ $$aETD
000007484 245__ $$aInfiltrating and resident myeloid cells in the central nervous system are neuroinflammatory mediators of cachexia during pancreatic cancer
000007484 260__ $$bOregon Health and Science University
000007484 269__ $$a2019
000007484 336__ $$aDissertation
000007484 502__ $$bPh.D.
000007484 520__ $$aCachexia is a devastating syndrome with cardinal features of anorexia, weight loss, and fatigue. This syndrome occurs during numerous chronic diseases, such as cancer, cirrhosis, congestive heart failure, and rheumatoid arthritis. While mechanisms of cachexia are still not well understood, our lab and others demonstrated that inflammation within distinct brain regions can cause signs and symptoms similar to those observed during cachexia. Specifically, inflammation in the mediobasal hypothalamus can drive aberrant activation of the weight- and activity-mediating neurons in the region, causing decreased food intake, loss of skeletal muscle, and decreased locomotor activity. Mechanisms by which inflammation generated in the periphery is translated to inflammation in the brain have yet to be elucidated. Furthermore, cellular sources of neuroinflammation during cachexia are not known. The purpose of this dissertation was to identify and characterize the role of immune cells in the brain during cancer cachexia.
000007484 542__ $$fIn copyright - single owner
000007484 650__ $$aCachexia$$015945
000007484 650__ $$aMicroglia$$030120
000007484 650__ $$aNeutrophils$$022885
000007484 650__ $$aPancreatic Neoplasms$$023517
000007484 650__ $$aBrain$$015788
000007484 6531_ $$aneuroimmunology
000007484 691__ $$aSchool of Medicine$$041369
000007484 692__ $$aVollum Institute$$041509
000007484 7001_ $$aBurfeind, Kevin
000007484 8564_ $$9d5d3b183-34e6-4378-a458-654c55a28838$$s109844421$$uhttps://digitalcollections.ohsu.edu/record/7484/files/burfeind.kevin.2019.pdf
000007484 905__ $$a/rest/prod/69/69/z1/30/6969z130f
000007484 909CO $$ooai:digitalcollections.ohsu.edu:7484$$pstudent-work
000007484 980__ $$aTheses and Dissertations