TY  - GEN
N2  - Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of malignancies, with a dismal survival rate and limited treatment options. Advances in therapeutic modalities are urgently needed not only to successfully restrain tumor growth, but to address the underlying physiological aberrations that drive significant morbidity and mortality in PDAC. Specifically, no therapies exist to treat cachexia, a complex metabolic and behavioral syndrome that is present in up to 85% of patients with PDAC. To address this therapeutic gap, I performed three main studies detailed over the course of this dissertation.
DO  - 10.6083/fj236261b
DO  - DOI
AB  - Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of malignancies, with a dismal survival rate and limited treatment options. Advances in therapeutic modalities are urgently needed not only to successfully restrain tumor growth, but to address the underlying physiological aberrations that drive significant morbidity and mortality in PDAC. Specifically, no therapies exist to treat cachexia, a complex metabolic and behavioral syndrome that is present in up to 85% of patients with PDAC. To address this therapeutic gap, I performed three main studies detailed over the course of this dissertation.
T1  - TLR7 as a therapeutic target for pancreatic ductal adenocarcinoma and cancer-associated cachexia
DA  - 2019
AU  - Michaelis, Katherine A.
L1  - https://digitalcollections.ohsu.edu/record/7492/files/michaelis.katherine.2019.pdf
PB  - Oregon Health and Science University
PY  - 2019
ID  - 7492
L4  - https://digitalcollections.ohsu.edu/record/7492/files/michaelis.katherine.2019.pdf
KW  - Immune Tolerance
KW  - Adenocarcinoma
KW  - Cachexia
KW  - Immunotherapy
KW  - Immunity
KW  - Physiology
KW  - Systems Biology
KW  - pancreatic ductal carcinomas
KW  - innate
KW  - immunology
TI  - TLR7 as a therapeutic target for pancreatic ductal adenocarcinoma and cancer-associated cachexia
Y1  - 2019
L2  - https://digitalcollections.ohsu.edu/record/7492/files/michaelis.katherine.2019.pdf
LK  - https://digitalcollections.ohsu.edu/record/7492/files/michaelis.katherine.2019.pdf
UR  - https://digitalcollections.ohsu.edu/record/7492/files/michaelis.katherine.2019.pdf
ER  -