000007495 001__ 7495
000007495 005__ 20231129124938.0
000007495 0247_ $$2DOI$$a10.6083/73666502h
000007495 037__ $$aETD
000007495 245__ $$aAlternative splicing of MR1 regulates T cell responses to mycobacteria
000007495 260__ $$bOregon Health and Science University
000007495 269__ $$a2019
000007495 336__ $$aDissertation
000007495 502__ $$bPh.D.
000007495 520__ $$aMR1-restricted T (MR1T) cells are part of a growing class of unconventional T cells that have emerged as important players in the early response to microbial infection. These cells, like other unconventional T cells, not only emerge from the thymus with immediate effector function, but also recognize non-peptide antigen produced by microbes. We show, using a panel of MR1T clones that share TCRa with differing TCRb chains, that the MR1T TCRb chain can contribute to recognition of both microbially infected dendritic cells, as well as distinguish between microbial ligand. These results suggest an important role in the TCRb chain in helping to sense microbial infection. However, given the wide range of antigen recognized by MR1T cells, as well as their capacity to produce inflammatory cytokines, and their enrichment in mucosal sites, likely in close proximity to commensals also capable of producing MR1T antigen, the question remains on how MR1T cell activation is regulated to prevent unwanted tissue damage or autoimmunity.
000007495 542__ $$fIn copyright - single owner
000007495 650__ $$aAntigen Presentation$$030374
000007495 650__ $$aAlternative Splicing$$029939
000007495 6531_ $$areceptors
000007495 6531_ $$aantigen
000007495 6531_ $$at cell
000007495 6531_ $$aimmunology
000007495 691__ $$aSchool of Medicine$$041369
000007495 692__ $$aDepartment of Biomedical Engineering$$041397
000007495 7001_ $$aNarayanan, Gitanjali A.
000007495 8564_ $$9fa3ce203-2409-4943-a4b5-d1f22ca40895$$s3802166$$uhttps://digitalcollections.ohsu.edu/record/7495/files/narayanan.gitanjali.2019.pdf
000007495 905__ $$a/rest/prod/73/66/65/02/73666502h
000007495 909CO $$ooai:digitalcollections.ohsu.edu:7495$$pstudent-work
000007495 980__ $$aTheses and Dissertations