@article{ETD,
      recid = {750},
      author = {Wille, Paul},
      title = {How human cytomaegalovirus glycoproteins mediate entry},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2011},
      number = {ETD},
      abstract = {This work examines the role of human cytomegalovirus  (HCMV) envelope glycoproteins in viral entry. Using genetic  and biochemical approaches, we show that gO acts as a  molecular chaperone for gH/gL ER export but dissociates  before virion assembly; deletion of gO reduces gH/gL  incorporation and blocks entry into fibroblasts and  epithelial/endothelial cells. We also demonstrate that gB  functions as the fusion protein: cells expressing gB  mediate entry of gB-deficient virions in trans, whereas  gH/gL cannot. These findings support a model where gH/gL  binds cellular receptors and interacts with gB to trigger  membrane fusion during HCMV entry.},
      url = {http://digitalcollections.ohsu.edu/record/750},
      doi = {https://doi.org/10.6083/M4PV6HC2},
}