TY  - GEN
AB  - Exchange of cerebrospinal fluid (CSF) with interstitial fluid (ISF) is a recently elaborated pathway by which solutes are trafficked into and out of the brain. This pathway has been implicated as a clearance mechanism for proteins such as amyloid β and tau, prior to pathogenic aggregation, a process characteristic of several neurodegenerative diseases. The mechanisms responsible for CSF-ISF exchange are poorly understood but have been linked to the expression of the astrocytic water channel aquaporin-4 (AQP4). AQP4 is unique in that it exhibits a profound localization to the perivascular spaces at which CSF-ISF exchange occurs, and that pathological states, including aging, dramatically reduce this localization. The significance of this loss of localization for CSF-ISF exchange and neurodegenerative disease has not been articulated. Here, we use imaging and cellular based approaches to study the role of AQP4 and the astrocytic endfoot in CSF-ISF exchange and aggregating protein clearance.
AU  - Simon, Matthew J.
DA  - 2019
DO  - 10.6083/6395w780w
DO  - DOI
ID  - 7502
KW  - alpha-Synuclein
KW  - Astrocytes
KW  - Glymphatic System
KW  - Cerebrospinal Fluid
KW  - alzheimer's disease
KW  - aquaporin-4
KW  - interstitial fluid
L1  - https://digitalcollections.ohsu.edu/record/7502/files/simon.matthew.2019.pdf
L2  - https://digitalcollections.ohsu.edu/record/7502/files/simon.matthew.2019.pdf
L4  - https://digitalcollections.ohsu.edu/record/7502/files/simon.matthew.2019.pdf
LK  - https://digitalcollections.ohsu.edu/record/7502/files/simon.matthew.2019.pdf
N2  - Exchange of cerebrospinal fluid (CSF) with interstitial fluid (ISF) is a recently elaborated pathway by which solutes are trafficked into and out of the brain. This pathway has been implicated as a clearance mechanism for proteins such as amyloid β and tau, prior to pathogenic aggregation, a process characteristic of several neurodegenerative diseases. The mechanisms responsible for CSF-ISF exchange are poorly understood but have been linked to the expression of the astrocytic water channel aquaporin-4 (AQP4). AQP4 is unique in that it exhibits a profound localization to the perivascular spaces at which CSF-ISF exchange occurs, and that pathological states, including aging, dramatically reduce this localization. The significance of this loss of localization for CSF-ISF exchange and neurodegenerative disease has not been articulated. Here, we use imaging and cellular based approaches to study the role of AQP4 and the astrocytic endfoot in CSF-ISF exchange and aggregating protein clearance.
PB  - Oregon Health and Science University
PY  - 2019
T1  - The role of AQP4 and the astrocytic endfoot in CSF-ISF exchange and brain waste clearance
TI  - The role of AQP4 and the astrocytic endfoot in CSF-ISF exchange and brain waste clearance
UR  - https://digitalcollections.ohsu.edu/record/7502/files/simon.matthew.2019.pdf
Y1  - 2019
ER  -