TY  - GEN
N2  - Fetal Alcohol Spectrum Disorders (FASD), which results from gestational ethanol (a short-chain primary alcohol) exposure, is the most common form of preventable intellectual disability.  Individuals with FASD have a variety of Central Nervous System dysfunctions, including impulsivity, difficulties with abstract thinking, problems with memory, and learning disabilities.  FASD is highly prevalent throughout the world; in the United States alone, it is estimated that 24-48 in 1,000 individuals have FASD.  While the mechanisms underlying the response of the developing brain to gestational ethanol exposure are not fully understood, a potential mechanism is tissue plasminogen activator (tPA), which is upregulated by ethanol, both in vivo and in vitro. The experiments in this dissertation examined the hypothesis that gestational ethanol exposure alters neuronal morphology, and that this alteration is, in part, due to astrocyte-mediated increases in tPA caused by ethanol.
DO  - 10.6083/x346d472h
DO  - DOI
AB  - Fetal Alcohol Spectrum Disorders (FASD), which results from gestational ethanol (a short-chain primary alcohol) exposure, is the most common form of preventable intellectual disability.  Individuals with FASD have a variety of Central Nervous System dysfunctions, including impulsivity, difficulties with abstract thinking, problems with memory, and learning disabilities.  FASD is highly prevalent throughout the world; in the United States alone, it is estimated that 24-48 in 1,000 individuals have FASD.  While the mechanisms underlying the response of the developing brain to gestational ethanol exposure are not fully understood, a potential mechanism is tissue plasminogen activator (tPA), which is upregulated by ethanol, both in vivo and in vitro. The experiments in this dissertation examined the hypothesis that gestational ethanol exposure alters neuronal morphology, and that this alteration is, in part, due to astrocyte-mediated increases in tPA caused by ethanol.
T1  - Fetal alcohol spectrum disorders:  alteration of neuronal morphology by ethanol, choline and tissue plasminogen activator
DA  - 2019
AU  - Goeke, Calla M.
L1  - https://digitalcollections.ohsu.edu/record/7516/files/goeke.calla.2019.pdf
PB  - Oregon Health and Science University
PY  - 2019
ID  - 7516
L4  - https://digitalcollections.ohsu.edu/record/7516/files/goeke.calla.2019.pdf
KW  - Fetal Alcohol Spectrum Disorders
KW  - Hippocampus
KW  - Tissue Plasminogen Activator
KW  - Ethanol
KW  - Choline
KW  - neuronal morphology
TI  - Fetal alcohol spectrum disorders:  alteration of neuronal morphology by ethanol, choline and tissue plasminogen activator
Y1  - 2019
L2  - https://digitalcollections.ohsu.edu/record/7516/files/goeke.calla.2019.pdf
LK  - https://digitalcollections.ohsu.edu/record/7516/files/goeke.calla.2019.pdf
UR  - https://digitalcollections.ohsu.edu/record/7516/files/goeke.calla.2019.pdf
ER  -