000007516 001__ 7516
000007516 005__ 20231129124939.0
000007516 0247_ $$2DOI$$a10.6083/x346d472h
000007516 037__ $$aETD
000007516 245__ $$aFetal alcohol spectrum disorders:  alteration of neuronal morphology by ethanol, choline and tissue plasminogen activator
000007516 260__ $$bOregon Health and Science University
000007516 269__ $$a2019
000007516 336__ $$aDissertation
000007516 502__ $$bPh.D.
000007516 520__ $$aFetal Alcohol Spectrum Disorders (FASD), which results from gestational ethanol (a short-chain primary alcohol) exposure, is the most common form of preventable intellectual disability.  Individuals with FASD have a variety of Central Nervous System dysfunctions, including impulsivity, difficulties with abstract thinking, problems with memory, and learning disabilities.  FASD is highly prevalent throughout the world; in the United States alone, it is estimated that 24-48 in 1,000 individuals have FASD.  While the mechanisms underlying the response of the developing brain to gestational ethanol exposure are not fully understood, a potential mechanism is tissue plasminogen activator (tPA), which is upregulated by ethanol, both in vivo and in vitro. The experiments in this dissertation examined the hypothesis that gestational ethanol exposure alters neuronal morphology, and that this alteration is, in part, due to astrocyte-mediated increases in tPA caused by ethanol.
000007516 542__ $$fIn copyright - single owner
000007516 650__ $$aFetal Alcohol Spectrum Disorders$$040252
000007516 650__ $$aHippocampus$$020217
000007516 650__ $$aTissue Plasminogen Activator$$024249
000007516 650__ $$aEthanol$$014406
000007516 650__ $$aCholine$$016602
000007516 6531_ $$aneuronal morphology
000007516 691__ $$aSchool of Medicine$$041369
000007516 692__ $$aDepartment of Behavioral Neuroscience$$041394
000007516 7001_ $$aGoeke, Calla M.
000007516 8564_ $$920e13a81-0ba5-43b6-85dc-d46de4fabc8e$$s2365303$$uhttps://digitalcollections.ohsu.edu/record/7516/files/goeke.calla.2019.pdf
000007516 905__ $$a/rest/prod/x3/46/d4/72/x346d472h
000007516 909CO $$ooai:digitalcollections.ohsu.edu:7516$$pstudent-work
000007516 980__ $$aTheses and Dissertations