000000752 001__ 752
000000752 005__ 20251216111936.0
000000752 0247_ $$2DOI$$a10.6083/M4FB50ZR
000000752 037__ $$aETD
000000752 245__ $$aElucidation of the roles of agouti related proteins in zebrafish
000000752 260__ $$bOregon Health and Science University
000000752 269__ $$a2012
000000752 336__ $$aDissertation
000000752 502__ $$bPh.D.
000000752 520__ $$aThe melanocortin system regulates diverse physiological functions in vertebrates, with unique adaptations in teleosts. Using zebrafish, we characterized two agouti proteins, AgRP and AgRP2. AgRP2, expressed in the pineal gland and regulated by light, antagonizes MC1R and mediates background adaptation via pineal-hypothalamic signaling independent of retinal input. AgRP neurons, unlike in mammals, directly project to the pituitary, influencing multiple endocrine axes and somatic growth through MC4R suppression. These findings reveal novel roles for AgRP2 in light-responsive pigmentation and demonstrate hypophysiotropic melanocortin regulation of growth and energy balance in teleosts, highlighting key evolutionary differences from mammals.
000000752 540__ $$fCC BY
000000752 542__ $$fIn copyright - single owner
000000752 650__ $$aAgouti-Related Protein$$037800
000000752 650__ $$aZebrafish$$028076
000000752 650__ $$aPro-Opiomelanocortin$$024602
000000752 650__ $$aMelanocortins$$037410
000000752 650__ $$aPigmentation$$024154
000000752 650__ $$aMSH Release-Inhibiting Hormone$$022481
000000752 650__ $$aPro-Opiomelanocortin$$024602
000000752 6531_ $$azebra danio
000000752 691__ $$aSchool of Medicine$$041369
000000752 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000000752 7001_ $$aZhang, Chao$$uOregon Health and Science University$$041354
000000752 8564_ $$93c6acec3-04a1-4362-97cd-b7ce2ced7893$$s4689234$$uhttps://digitalcollections.ohsu.edu/record/752/files/755_etd.pdf$$ePublic$$26aba924aad102f65a168a153b79b2ed5$$31
000000752 905__ $$a/rest/prod/r2/07/tp/35/r207tp357
000000752 909CO $$ooai:digitalcollections.ohsu.edu:752$$pstudent-work
000000752 980__ $$aTheses and Dissertations