000007535 001__ 7535
000007535 005__ 20251008142144.0
000007535 0247_ $$2DOI$$a10.6083/2b88qc733
000007535 037__ $$aETD
000007535 245__ $$aA multi-modal investigation of the developmental origins of congenital heart defects in avian embryos
000007535 260__ $$bOregon Health and Science University
000007535 269__ $$a2019
000007535 336__ $$aThesis
000007535 502__ $$bM.S.
000007535 502__ $$gBiomedical Engineering
000007535 520__ $$aMaternal conditions that disrupt the normal embryonic environment during heart development can lead to structural defects in the heart, ultimately compromising the heart's function and leading to increased morbidity and mortality. Avian models of cardiovascular development have played a key role in elucidating the mechanisms by which congenital heart defects form during critical periods of early heart development. However, current avian models are restricted to narrow developmental windows, thereby limiting one's ability to study the manifestation of cardiac defects over a larger, more complete timescale. The work presented in this thesis uses novel techniques in an avian model coupled with multiscale imaging modalities to study how transient interventions during early heart formation affect the overall development of the heart.
000007535 542__ $$fIn copyright - single owner
000007535 650__ $$aPhenotype$$023948
000007535 650__ $$aAnimals$$014770
000007535 650__ $$aHeart$$019927
000007535 650__ $$aModels, Animal$$033025
000007535 650__ $$aHeart Defects, Congenital$$019936
000007535 650__ $$aMicroscopy, Electron$$022283
000007535 691__ $$aSchool of Medicine$$041369
000007535 692__ $$aDepartment of Biomedical Engineering$$041397
000007535 7001_ $$aRykiel, Graham$$uOregon Health and Science University$$041354$$10000-0003-0918-3926
000007535 7201_ $$aRugonyi, Sandra$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000007535 8564_ $$9f0eb3ceb-9a84-4fe2-a94e-50f3c9cd77cb$$s4438367$$uhttps://digitalcollections.ohsu.edu/record/7535/files/rykiel.graham.2019.pdf$$ePublic$$2eea60f35ae0aec5929234452b7463759$$31
000007535 905__ $$a/rest/prod/2b/88/qc/73/2b88qc733
000007535 909CO $$ooai:digitalcollections.ohsu.edu:7535$$pstudent-work
000007535 980__ $$aTheses and Dissertations