000007550 001__ 7550
000007550 005__ 20231129124941.0
000007550 0247_ $$2DOI$$a10.6083/s7526d10t
000007550 037__ $$aETD
000007550 245__ $$aThe heterogeneous microenvironment of malignant primary and metastatic central nervous system tumors
000007550 260__ $$bOregon Health and Science University
000007550 269__ $$a2019
000007550 336__ $$aDissertation
000007550 502__ $$bPh.D.
000007550 520__ $$aMalignant brain tumors remain incurable and improving outcomes will require personalized treatment strategies. In personalized medicine, therapeutics are tailored to each tumor. To apply personalized medicine to brain tumors, a more thorough understanding of therapeutically actionable tumor features in individuals and patient cohorts is needed. Actionable tumor features include genetic mutations, aberrantly expressed proteins, and tumorigenic microenvironment elements. In brain tumors, applying personalized treatment strategies is complicated by multi-layered heterogeneity, biological complexity, and difficult drug delivery. In this dissertation I investigated factors that currently hinder the use of personalized medicine for malignant brain tumors.
000007550 542__ $$fIn copyright - single owner
000007550 650__ $$aPrecision Medicine$$038927
000007550 650__ $$aGlioblastoma$$019547
000007550 650__ $$aMedical Oncology$$021943
000007550 650__ $$aNeoplasms$$022758
000007550 650__ $$aBrain$$015788
000007550 650__ $$aTumor Microenvironment$$039473
000007550 6531_ $$ametastasis
000007550 691__ $$aSchool of Medicine$$041369
000007550 692__ $$aVollum Institute$$041509
000007550 7001_ $$aKersch, Cymon N.
000007550 8564_ $$975ebb509-e65e-4dc7-9813-dd24cb5fe96c$$s36707988$$uhttps://digitalcollections.ohsu.edu/record/7550/files/kersch.cymon.2019.pdf
000007550 905__ $$a/rest/prod/s7/52/6d/10/s7526d10t
000007550 909CO $$ooai:digitalcollections.ohsu.edu:7550$$pstudent-work
000007550 980__ $$aTheses and Dissertations