000007567 001__ 7567
000007567 005__ 20240124114246.0
000007567 0247_ $$2DOI$$a10.6083/6m311p94g
000007567 037__ $$aETD
000007567 245__ $$aTemporomandibular joint articular disc:  development-guided regeneration
000007567 260__ $$bOregon Health and Science University
000007567 269__ $$a2019
000007567 336__ $$aDissertation
000007567 502__ $$bPh.D.
000007567 520__ $$aApproximately one million individuals with temporomandibular joint (TMJ) disorders experience advanced symptoms, such as disc perforations, necessitating the removal of the articular disc (AD). The TMJ AD is defined as fibrocartilage residing between the skull and jaw bones. The goals of my work were to study the developmental origin of the tissue defined as the AD, and to identify and use an appropriate cell source for TE of the AD. My results indicate a tenogenic origin of the AD that is not the current classification of the AD tissue. Furthermore, I was able to characterize and engineer tissue with a cloneable population of progenitor cells isolated from the AD itself. These results could have major impacts on the tissue engineering and clinical approaches to TMJ tissue regeneration.
000007567 542__ $$fIn copyright - single owner
000007567 650__ $$aTissue Engineering$$033051
000007567 650__ $$aTemporomandibular Joint$$026827
000007567 650__ $$aGrowth and Development$$036136
000007567 6531_ $$atmj
000007567 6531_ $$aarticular disc
000007567 6531_ $$aprogenitor cells
000007567 691__ $$aSchool of Dentistry$$041368
000007567 692__ $$aDepartment of Science and Engineering$$041447
000007567 7001_ $$aWeekes, Kenneth J.
000007567 8564_ $$917d2b766-8fe2-43b1-85b3-6f65ccf045f8$$s55310705$$uhttps://digitalcollections.ohsu.edu/record/7567/files/weekes.kenneth.2019.pdf
000007567 905__ $$a/rest/prod/6m/31/1p/94/6m311p94g
000007567 909CO $$ooai:digitalcollections.ohsu.edu:7567$$pstudent-work
000007567 980__ $$aTheses and Dissertations