TY  - GEN
N2  - The prognosis for patients with the genetic neurological disorder Huntington's disease (HD) is incredibly poor. HD onsets in midlife, causes a variety of severe and debilitating symptoms, progresses over 10-15 years, and always leads to death. There are currently no treatments that can slow the progression of the disease in any way. Thus, there is tremendous need to discover new therapeutic approaches that can slow or halt disease progression and thereby improve quality of life for patients. In the studies presented here, I characterized the roles of glucocorticoids and the anterior cingulate cortex in HD symptomology, with the overarching goal of assessing the suitability of these two systems as possible points of therapeutic intervention for HD.
DO  - 10.6083/m44j0dph
DO  - DOI
AB  - The prognosis for patients with the genetic neurological disorder Huntington's disease (HD) is incredibly poor. HD onsets in midlife, causes a variety of severe and debilitating symptoms, progresses over 10-15 years, and always leads to death. There are currently no treatments that can slow the progression of the disease in any way. Thus, there is tremendous need to discover new therapeutic approaches that can slow or halt disease progression and thereby improve quality of life for patients. In the studies presented here, I characterized the roles of glucocorticoids and the anterior cingulate cortex in HD symptomology, with the overarching goal of assessing the suitability of these two systems as possible points of therapeutic intervention for HD.
T1  - The roles of glucocorticoids and the anterior cingulate cortex in Huntington's Disease symptomology and therapeutics
DA  - 2018
AU  - Dufour, Brett D.
L1  - https://digitalcollections.ohsu.edu/record/7572/files/Dufour.Brett.2018.pdf
PB  - Oregon Health and Science University
PY  - 2018
ID  - 7572
L4  - https://digitalcollections.ohsu.edu/record/7572/files/Dufour.Brett.2018.pdf
KW  - Neuropathology
KW  - Gyrus Cinguli
KW  - Affect
KW  - Metabolism
KW  - Glucocorticoids
KW  - anterior cingulate
KW  - huntington's disease
KW  - mood
TI  - The roles of glucocorticoids and the anterior cingulate cortex in Huntington's Disease symptomology and therapeutics
Y1  - 2018
L2  - https://digitalcollections.ohsu.edu/record/7572/files/Dufour.Brett.2018.pdf
LK  - https://digitalcollections.ohsu.edu/record/7572/files/Dufour.Brett.2018.pdf
UR  - https://digitalcollections.ohsu.edu/record/7572/files/Dufour.Brett.2018.pdf
ER  -