000007572 001__ 7572
000007572 005__ 20231129124937.0
000007572 0247_ $$2DOI$$a10.6083/m44j0dph
000007572 037__ $$aETD
000007572 245__ $$aThe roles of glucocorticoids and the anterior cingulate cortex in Huntington's Disease symptomology and therapeutics
000007572 260__ $$bOregon Health and Science University
000007572 269__ $$a2018
000007572 336__ $$aDissertation
000007572 502__ $$bPh.D.
000007572 520__ $$aThe prognosis for patients with the genetic neurological disorder Huntington's disease (HD) is incredibly poor. HD onsets in midlife, causes a variety of severe and debilitating symptoms, progresses over 10-15 years, and always leads to death. There are currently no treatments that can slow the progression of the disease in any way. Thus, there is tremendous need to discover new therapeutic approaches that can slow or halt disease progression and thereby improve quality of life for patients. In the studies presented here, I characterized the roles of glucocorticoids and the anterior cingulate cortex in HD symptomology, with the overarching goal of assessing the suitability of these two systems as possible points of therapeutic intervention for HD.
000007572 542__ $$fIn copyright - single owner
000007572 650__ $$aNeuropathology$$011381
000007572 650__ $$aGyrus Cinguli$$019793
000007572 650__ $$aAffect$$014330
000007572 650__ $$aMetabolism$$022101
000007572 650__ $$aGlucocorticoids$$019575
000007572 6531_ $$aanterior cingulate
000007572 6531_ $$ahuntington's disease
000007572 6531_ $$amood
000007572 691__ $$aSchool of Medicine$$041369
000007572 7001_ $$aDufour, Brett D.
000007572 8564_ $$971e11f1b-9075-4545-b50e-322e1c5f87ba$$s16629717$$uhttps://digitalcollections.ohsu.edu/record/7572/files/Dufour.Brett.2018.pdf
000007572 905__ $$a/rest/prod/nz/80/60/21/nz8060216
000007572 909CO $$ooai:digitalcollections.ohsu.edu:7572$$pstudent-work
000007572 980__ $$aTheses and Dissertations