000007573 001__ 7573
000007573 005__ 20231129124934.0
000007573 0247_ $$2DOI$$a10.6083/m4hm580w
000007573 037__ $$aETD
000007573 245__ $$aInvolvement of the dorsal hippocampus and histone deacetylase 3 in reward-seeking behaviors
000007573 260__ $$bOregon Health and Science University
000007573 269__ $$a2017
000007573 336__ $$aDissertation
000007573 502__ $$bPh.D.
000007573 520__ $$aSubstance use disorder is a chronic, often relapsing disease that can include a loss of behavioral inhibition and compulsive drug-seeking. Acquisition of a reward seeking behavior often begins when cues are paired with rewards. These cues are thought to influence subsequent extinction (animal model of exposure-based therapy) and relapse-like behavior, both in humans and animals. My work found that acquisition and extinction of cocaine-induced conditioned place preference (CPP) were sensitive to the configuration of the apparatus and that the dorsal hippocampus (DH) regulated expression of CPP after acquisition and extinction.
000007573 542__ $$fIn copyright - single owner
000007573 650__ $$aHippocampus$$020217
000007573 650__ $$aLearning$$021358
000007573 650__ $$aReward$$025422
000007573 650__ $$aBehavioral Sciences$$015417
000007573 6531_ $$ahistone deacetylase 3
000007573 691__ $$aSchool of Medicine$$041369
000007573 7001_ $$aHitchcock, Leah
000007573 8564_ $$9d7d168de-890c-4568-bad1-728711e8b77b$$s2807987$$uhttps://digitalcollections.ohsu.edu/record/7573/files/Hitchcock.Leah.2017.pdf
000007573 905__ $$a/rest/prod/t1/48/fh/66/t148fh66v
000007573 909CO $$ooai:digitalcollections.ohsu.edu:7573$$pstudent-work
000007573 980__ $$aTheses and Dissertations