@article{ETD, recid = {7576}, author = {Lane, Ryan S.}, title = {The contribution of lymphatic and blood endothelial cell PD-L1 to leukocyte accumulation in skin}, publisher = {Oregon Health and Science University}, school = {Ph.D.}, address = {2019}, number = {ETD}, abstract = {Mechanisms of immune suppression in peripheral tissues counteract protective immu-nity to prevent immunopathology and are coopted by tumors for immune evasion. Blood and lymphatic vessels contribute to the immune landscape within a tissue by providing selective entry and exit routes, respectively. The work here investigates potential mecha-nisms by which peripheral lymphatic and blood vessel expression of the T cell inhibitory molecule PD-L1, regulate antitumor immunity. Here I test the hypothesis that PD-L1 expression by blood and lymphatic vasculature limits T cell accumulation in skin and tumors.}, url = {http://digitalcollections.ohsu.edu/record/7576}, doi = {https://doi.org/10.6083/z603qx96t}, }