TY  - GEN
N2  - Mechanisms of immune suppression in peripheral tissues counteract protective immu-nity to prevent immunopathology and are coopted by tumors for immune evasion. Blood and lymphatic vessels contribute to the immune landscape within a tissue by providing selective entry and exit routes, respectively. The work here investigates potential mecha-nisms by which peripheral lymphatic and blood vessel expression of the T cell inhibitory molecule PD-L1, regulate antitumor immunity. Here I test the hypothesis that PD-L1 expression by blood and lymphatic vasculature limits T cell accumulation in skin and tumors.
DO  - 10.6083/z603qx96t
DO  - DOI
AB  - Mechanisms of immune suppression in peripheral tissues counteract protective immu-nity to prevent immunopathology and are coopted by tumors for immune evasion. Blood and lymphatic vessels contribute to the immune landscape within a tissue by providing selective entry and exit routes, respectively. The work here investigates potential mecha-nisms by which peripheral lymphatic and blood vessel expression of the T cell inhibitory molecule PD-L1, regulate antitumor immunity. Here I test the hypothesis that PD-L1 expression by blood and lymphatic vasculature limits T cell accumulation in skin and tumors.
T1  - The contribution of lymphatic and blood endothelial cell PD-L1 to leukocyte accumulation in skin
DA  - 2019
AU  - Lane, Ryan S.
L1  - https://digitalcollections.ohsu.edu/record/7576/files/lane.ryan.2019.pdf
PB  - Oregon Health and Science University
PY  - 2019
ID  - 7576
L4  - https://digitalcollections.ohsu.edu/record/7576/files/lane.ryan.2019.pdf
KW  - Endothelial Cells
KW  - Melanoma
KW  - Immunotherapy
KW  - Tumor Microenvironment
KW  - transmigration
KW  - lymphatic vessel
TI  - The contribution of lymphatic and blood endothelial cell PD-L1 to leukocyte accumulation in skin
Y1  - 2019
L2  - https://digitalcollections.ohsu.edu/record/7576/files/lane.ryan.2019.pdf
LK  - https://digitalcollections.ohsu.edu/record/7576/files/lane.ryan.2019.pdf
UR  - https://digitalcollections.ohsu.edu/record/7576/files/lane.ryan.2019.pdf
ER  -