000007576 001__ 7576
000007576 005__ 20240112093818.0
000007576 0247_ $$2DOI$$a10.6083/z603qx96t
000007576 037__ $$aETD
000007576 245__ $$aThe contribution of lymphatic and blood endothelial cell PD-L1 to leukocyte accumulation in skin
000007576 260__ $$bOregon Health and Science University
000007576 269__ $$a2019
000007576 336__ $$aDissertation
000007576 502__ $$bPh.D.
000007576 520__ $$aMechanisms of immune suppression in peripheral tissues counteract protective immu-nity to prevent immunopathology and are coopted by tumors for immune evasion. Blood and lymphatic vessels contribute to the immune landscape within a tissue by providing selective entry and exit routes, respectively. The work here investigates potential mecha-nisms by which peripheral lymphatic and blood vessel expression of the T cell inhibitory molecule PD-L1, regulate antitumor immunity. Here I test the hypothesis that PD-L1 expression by blood and lymphatic vasculature limits T cell accumulation in skin and tumors.
000007576 542__ $$fIn copyright - single owner
000007576 650__ $$aEndothelial Cells$$035222
000007576 650__ $$aMelanoma$$021989
000007576 650__ $$aImmunotherapy$$020724
000007576 650__ $$aTumor Microenvironment$$039473
000007576 6531_ $$atransmigration
000007576 6531_ $$alymphatic vessel
000007576 691__ $$aSchool of Medicine$$041369
000007576 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000007576 7001_ $$aLane, Ryan S.
000007576 8564_ $$94e3fe7bc-116e-42ea-b640-858884eb6f4c$$s31518813$$uhttps://digitalcollections.ohsu.edu/record/7576/files/lane.ryan.2019.pdf
000007576 905__ $$a/rest/prod/z6/03/qx/96/z603qx96t
000007576 909CO $$ooai:digitalcollections.ohsu.edu:7576$$pstudent-work
000007576 980__ $$aTheses and Dissertations