@article{ETD,
      school = {Ph.D.},
      author = {Mammel, Anna E.},
      url = {http://digitalcollections.ohsu.edu/record/7580},
      title = {Distinct roles for the endosomal regulators Mtmr5 and  Mtmr13 in axon radial sorting and myelination},
      publisher = {Oregon Health and Science University},
      abstract = {Nearly half of the proteins linked to demyelinating  subtypes of Charcot-Marie-Tooth disease regulate  endo-lysosomal trafficking. Most of these proteins are  expressed in all human tissues, yet defects caused by  loss-of-function mutations are largely isolated to the  peripheral nervous system. This observation suggests that  myelinating Schwann cells are particularly vulnerable to  endosomal trafficking defects, yet the molecular mechanisms  that orchestrate this cell-specific vulnerability remain  unclear. We hypothesize that endosomal trafficking provides  the specific control needed to regulate pro-myelination  signals and coordinate cytoskeletal rearrangements during  axon sorting and myelination.  All cells require the  trafficking of membrane receptors, but the work described  within this dissertation suggests that Schwann cells rely  heavily on endo-lysosomal membrane trafficking for all  aspects of their biology. Highlighting why changes in  phosphoinositide hydrolysis and endosomal trafficking cause  peripheral neuropathy.},
      number = {ETD},
      doi = {https://doi.org/10.6083/js956g337},
      recid = {7580},
      address = {2019},
}