@article{ETD,
      recid = {7583},
      author = {Yoder, Nathan B.},
      title = {Gating and modulation of acid-sensing ion channels},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2019},
      number = {ETD},
      abstract = {By leveraging the inhibitory effects of divalent cations  Ca2+ and Ba2+, I determined the structure of a homotrimeric  ASIC in a high pH resting conformation by both x-ray  crystallography and cryo-electron microscopy (cryo-EM).  These results demonstrated that collapse of the acidic  pocket is required for proton-dependent activation and that  flexible linkers within the palm domain rearrange to enable  channel desensitization. Moreover, the location of  state-dependent Ba2+ sites within the acidic pocket and  central vestibule, determined by anomalous scattering x-ray  crystallography, indicates that inhibition of  proton-dependent gating by divalent cations is at least  partly due to competition for similar binding sites.},
      url = {http://digitalcollections.ohsu.edu/record/7583},
      doi = {https://doi.org/10.6083/0p0967470},
}