TY  - GEN
N2  - Parkinson's disease (PD) is a neurodegenerative disorder characterized by declining motor function. While the etiology is not understood, a hallmark of PD is a loss of dopaminergic cells in the substantia nigra pars compacta (SNpc), which provide the dopamine tone for the basal ganglia. The decline in dopamine levels in the striatum, the projection target of the SNpc, leads to a dysregulation of signaling between the nuclei of the basal ganglia, leading to decreased output from the motor thalamus and consequent motor dysfunction. Current therapies provide symptomatic relief, but to date, no treatment has been proven capable of altering PD progression, necessitating the need for a different treatment strategy.
DO  - 10.6083/qz20st16p
DO  - DOI
AB  - Parkinson's disease (PD) is a neurodegenerative disorder characterized by declining motor function. While the etiology is not understood, a hallmark of PD is a loss of dopaminergic cells in the substantia nigra pars compacta (SNpc), which provide the dopamine tone for the basal ganglia. The decline in dopamine levels in the striatum, the projection target of the SNpc, leads to a dysregulation of signaling between the nuclei of the basal ganglia, leading to decreased output from the motor thalamus and consequent motor dysfunction. Current therapies provide symptomatic relief, but to date, no treatment has been proven capable of altering PD progression, necessitating the need for a different treatment strategy.
T1  - The role of cortical disinhibition in a progressive mouse model of Parkinson's disease
DA  - 2019
AU  - Hood, Rebecca L.
L1  - https://digitalcollections.ohsu.edu/record/7589/files/hood.rebecca.2019.pdf
PB  - Oregon Health and Science University
PY  - 2019
ID  - 7589
L4  - https://digitalcollections.ohsu.edu/record/7589/files/hood.rebecca.2019.pdf
KW  - Basal Ganglia
KW  - Subthalamic Nucleus
KW  - Dopaminergic Neurons
KW  - Motor Cortex
KW  - Substantia Nigra
KW  - parkinson's disease
TI  - The role of cortical disinhibition in a progressive mouse model of Parkinson's disease
Y1  - 2019
L2  - https://digitalcollections.ohsu.edu/record/7589/files/hood.rebecca.2019.pdf
LK  - https://digitalcollections.ohsu.edu/record/7589/files/hood.rebecca.2019.pdf
UR  - https://digitalcollections.ohsu.edu/record/7589/files/hood.rebecca.2019.pdf
ER  -