000007589 001__ 7589
000007589 005__ 20231129124941.0
000007589 0247_ $$2DOI$$a10.6083/qz20st16p
000007589 037__ $$aETD
000007589 245__ $$aThe role of cortical disinhibition in a progressive mouse model of Parkinson's disease
000007589 260__ $$bOregon Health and Science University
000007589 269__ $$a2019
000007589 336__ $$aDissertation
000007589 502__ $$bPh.D.
000007589 520__ $$aParkinson's disease (PD) is a neurodegenerative disorder characterized by declining motor function. While the etiology is not understood, a hallmark of PD is a loss of dopaminergic cells in the substantia nigra pars compacta (SNpc), which provide the dopamine tone for the basal ganglia. The decline in dopamine levels in the striatum, the projection target of the SNpc, leads to a dysregulation of signaling between the nuclei of the basal ganglia, leading to decreased output from the motor thalamus and consequent motor dysfunction. Current therapies provide symptomatic relief, but to date, no treatment has been proven capable of altering PD progression, necessitating the need for a different treatment strategy.
000007589 542__ $$fIn copyright - single owner
000007589 650__ $$aBasal Ganglia$$015374
000007589 650__ $$aSubthalamic Nucleus$$032470
000007589 650__ $$aDopaminergic Neurons$$039537
000007589 650__ $$aMotor Cortex$$022452
000007589 650__ $$aSubstantia Nigra$$026530
000007589 6531_ $$aparkinson's disease
000007589 691__ $$aSchool of Medicine$$041369
000007589 692__ $$aDepartment of Behavioral Neuroscience$$041394
000007589 7001_ $$aHood, Rebecca L.
000007589 8564_ $$92ba6176b-fb5b-402f-8077-5ede7119339e$$s2311737$$uhttps://digitalcollections.ohsu.edu/record/7589/files/hood.rebecca.2019.pdf
000007589 905__ $$a/rest/prod/qz/20/st/16/qz20st16p
000007589 909CO $$ooai:digitalcollections.ohsu.edu:7589$$pstudent-work
000007589 980__ $$aTheses and Dissertations