TY - GEN AB - Despite incredible advances in the recruitment and phenotyping of patients for genomewide association studies (GWAS) in the past decade, the ability to ascertain the causes of complex disease remains a significant challenge. Recent research implies that instead of single variants of large effect, many variants of extremely small effect represent the majority of signal associated with genetic disease. We believe this work is an important step toward increasing the predictive power and interpretability of genetic risk score methods, and that the evolution of such score will help inform and direct research in genetic disease to the benefit of patients and clinicians. AU - Swan, Ryan DA - 2019 DO - 10.6083/nz806022g DO - DOI ID - 7590 KW - Rare Diseases KW - Humans KW - Genome-Wide Association Study KW - Infant KW - Multifactorial Inheritance KW - Retinopathy of Prematurity KW - newborn L1 - https://digitalcollections.ohsu.edu/record/7590/files/swan.ryan.2019.pdf L2 - https://digitalcollections.ohsu.edu/record/7590/files/swan.ryan.2019.pdf L4 - https://digitalcollections.ohsu.edu/record/7590/files/swan.ryan.2019.pdf LK - https://digitalcollections.ohsu.edu/record/7590/files/swan.ryan.2019.pdf N2 - Despite incredible advances in the recruitment and phenotyping of patients for genomewide association studies (GWAS) in the past decade, the ability to ascertain the causes of complex disease remains a significant challenge. Recent research implies that instead of single variants of large effect, many variants of extremely small effect represent the majority of signal associated with genetic disease. We believe this work is an important step toward increasing the predictive power and interpretability of genetic risk score methods, and that the evolution of such score will help inform and direct research in genetic disease to the benefit of patients and clinicians. PB - Oregon Health and Science University PY - 2019 T1 - Development of a network-based measure of genetic risk and its application in preterm birth and retinopathy of prematurity TI - Development of a network-based measure of genetic risk and its application in preterm birth and retinopathy of prematurity UR - https://digitalcollections.ohsu.edu/record/7590/files/swan.ryan.2019.pdf Y1 - 2019 ER -