000007590 001__ 7590
000007590 005__ 20231129124938.0
000007590 0247_ $$2DOI$$a10.6083/nz806022g
000007590 037__ $$aETD
000007590 245__ $$aDevelopment of a network-based measure of genetic risk and its  application in preterm birth and retinopathy of prematurity
000007590 260__ $$bOregon Health and Science University
000007590 269__ $$a2019
000007590 336__ $$aDissertation
000007590 502__ $$bPh.D.
000007590 520__ $$aDespite incredible advances in the recruitment and phenotyping of patients for genomewide association studies (GWAS) in the past decade, the ability to ascertain the causes of complex disease remains a significant challenge. Recent research implies that instead of single variants of large effect, many variants of extremely small effect represent the majority of signal associated with genetic disease. We believe this work is an important step toward increasing the predictive power and interpretability of genetic risk score methods, and that the evolution of such score will help inform and direct research in genetic disease to the benefit of patients and clinicians.
000007590 542__ $$fIn copyright - single owner
000007590 650__ $$aRare Diseases$$034662
000007590 650__ $$aHumans$$020376
000007590 650__ $$aGenome-Wide Association Study$$038168
000007590 650__ $$aInfant$$020774
000007590 650__ $$aMultifactorial Inheritance$$032399
000007590 650__ $$aRetinopathy of Prematurity$$025405
000007590 6531_ $$anewborn
000007590 691__ $$aSchool of Medicine$$041369
000007590 7001_ $$aSwan, Ryan
000007590 8564_ $$9fe260716-211e-462a-87d8-c8995685c2c3$$s10007845$$uhttps://digitalcollections.ohsu.edu/record/7590/files/swan.ryan.2019.pdf
000007590 901__ $$aCurrently embargoed
000007590 905__ $$a/rest/prod/nz/80/60/22/nz806022g
000007590 909CO $$ooai:digitalcollections.ohsu.edu:7590$$pstudent-work
000007590 980__ $$aTheses and Dissertations