TY  - GEN
N2  - Leukocytes recruited to and persistent within chronically inflamed tissues play critical roles in fostering neoplastic progression. Immunotherapies designed to reprogram protumoral immune microenvironments have gained clinical traction in many solid tumors, but pancreatic ductal adenocarcinoma (PDAC) has thus far failed to respond to single-agent immunotherapy. Recent preclinical studies have indicated that combinatorial immunotherapy may yield improved response rates in PDAC, especially combinations intended to both reprogram immunosuppressive myeloid cells and antagonize T cell inhibitory pathways. However, the immune microenvironment of human PDAC is heterogeneous and has not been extensively characterized in situ. As such, functionally significant immune biomarkers are urgently needed to better stratify patients for appropriate immunotherapeutic combinations.
DO  - 10.6083/gf06g318p
DO  - DOI
AB  - Leukocytes recruited to and persistent within chronically inflamed tissues play critical roles in fostering neoplastic progression. Immunotherapies designed to reprogram protumoral immune microenvironments have gained clinical traction in many solid tumors, but pancreatic ductal adenocarcinoma (PDAC) has thus far failed to respond to single-agent immunotherapy. Recent preclinical studies have indicated that combinatorial immunotherapy may yield improved response rates in PDAC, especially combinations intended to both reprogram immunosuppressive myeloid cells and antagonize T cell inhibitory pathways. However, the immune microenvironment of human PDAC is heterogeneous and has not been extensively characterized in situ. As such, functionally significant immune biomarkers are urgently needed to better stratify patients for appropriate immunotherapeutic combinations.
T1  - Immune contexture of pancreatitis and pancreatic cancer: implications for immunotherapy
DA  - 2019
AU  - Liudahl, Shannon M.
L1  - https://digitalcollections.ohsu.edu/record/7591/files/liudahl.shannon.2019.pdf
PB  - Oregon Health and Science University
PY  - 2019
ID  - 7591
L4  - https://digitalcollections.ohsu.edu/record/7591/files/liudahl.shannon.2019.pdf
KW  - Immunohistochemistry
KW  - B-Lymphocytes
KW  - Tumor Microenvironment
KW  - Immunotherapy
KW  - Pancreatitis
KW  - pancreatic ductal carcinoma
TI  - Immune contexture of pancreatitis and pancreatic cancer: implications for immunotherapy
Y1  - 2019
L2  - https://digitalcollections.ohsu.edu/record/7591/files/liudahl.shannon.2019.pdf
LK  - https://digitalcollections.ohsu.edu/record/7591/files/liudahl.shannon.2019.pdf
UR  - https://digitalcollections.ohsu.edu/record/7591/files/liudahl.shannon.2019.pdf
ER  -