TY - THES AB - Obesity is a public health concern with rising incidence and prevalence rates. Research exploring the metabolomic biomarkers for obesity suggests a potential association between elevated acylcarnitine concentrations in individuals with obesity compared to lean controls. Low-carbohydrate (LC) and high-complex-carbohydrate (HCC) dietary patterns are commonly followed by individuals with overweight and obesity seeking to lose weight. Yet, little is known about how these diets affect circulating acylcarnitine concentrations in combination with changes in body mass, lean mass, and fat mass. The goal of this secondary analysis of data obtained from the Comparison of Health Benefits and Risks of High-Carbohydrate, Low-Fat or Very-Low-Carbohydrate Diets for Weight Loss Study was to determine the effect of LC and HCC dietary interventions on circulating acylcarnitine concentrations among healthy adults with overweight and obesity. The first aim was to describe the impact of consuming a LC or HCC diet on fasting acylcarnitine concentrations at baseline and 2, 4, 6, and 18-weeks after dietary intervention. The second aim was to define the relationships between changes in lean mass, fat mass, and fasting acylcarnitine concentrations within and between the ad libitum LC diet group and the energy-matched HCC diet group. AU - Attema, Kathryn J. DA - 2017 DO - 10.6083/m44q7tj2 DO - DOI ID - 7601 KW - Carnitine KW - Obesity KW - Body Composition KW - Weight Loss KW - low carbohydrate diet KW - fat restricted diet L1 - https://digitalcollections.ohsu.edu/record/7601/files/Attema.Kathryn.2017.pdf L2 - https://digitalcollections.ohsu.edu/record/7601/files/Attema.Kathryn.2017.pdf L4 - https://digitalcollections.ohsu.edu/record/7601/files/Attema.Kathryn.2017.pdf LK - https://digitalcollections.ohsu.edu/record/7601/files/Attema.Kathryn.2017.pdf N2 - Obesity is a public health concern with rising incidence and prevalence rates. Research exploring the metabolomic biomarkers for obesity suggests a potential association between elevated acylcarnitine concentrations in individuals with obesity compared to lean controls. Low-carbohydrate (LC) and high-complex-carbohydrate (HCC) dietary patterns are commonly followed by individuals with overweight and obesity seeking to lose weight. Yet, little is known about how these diets affect circulating acylcarnitine concentrations in combination with changes in body mass, lean mass, and fat mass. The goal of this secondary analysis of data obtained from the Comparison of Health Benefits and Risks of High-Carbohydrate, Low-Fat or Very-Low-Carbohydrate Diets for Weight Loss Study was to determine the effect of LC and HCC dietary interventions on circulating acylcarnitine concentrations among healthy adults with overweight and obesity. The first aim was to describe the impact of consuming a LC or HCC diet on fasting acylcarnitine concentrations at baseline and 2, 4, 6, and 18-weeks after dietary intervention. The second aim was to define the relationships between changes in lean mass, fat mass, and fasting acylcarnitine concentrations within and between the ad libitum LC diet group and the energy-matched HCC diet group. PB - Oregon Health and Science University PY - 2017 T1 - Impact of high-complex-carbohydrate and low-carbohydrate diets and resulting body mass loss on circulating acylcarnitine concentrations in healthy adults with overweight and obesity TI - Impact of high-complex-carbohydrate and low-carbohydrate diets and resulting body mass loss on circulating acylcarnitine concentrations in healthy adults with overweight and obesity UR - https://digitalcollections.ohsu.edu/record/7601/files/Attema.Kathryn.2017.pdf Y1 - 2017 ER -