TY  - THES
N2  - Obesity is a public health concern with rising incidence and prevalence rates. Research exploring the metabolomic biomarkers for obesity suggests a potential association between elevated acylcarnitine concentrations in individuals with obesity compared to lean controls. Low-carbohydrate (LC) and high-complex-carbohydrate (HCC) dietary patterns are commonly followed by individuals with overweight and obesity seeking to lose weight. Yet, little is known about how these diets affect circulating acylcarnitine concentrations in combination with changes in body mass, lean mass, and fat mass.  
The goal of this secondary analysis of data obtained from the Comparison of Health Benefits and Risks of High-Carbohydrate, Low-Fat or Very-Low-Carbohydrate Diets for Weight Loss Study was to determine the effect of LC and HCC dietary interventions on circulating acylcarnitine concentrations among healthy adults with overweight and obesity. The first aim was to describe the impact of consuming a LC or HCC diet on fasting acylcarnitine concentrations at baseline and 2, 4, 6, and 18-weeks after dietary intervention. The second aim was to define the relationships between changes in lean mass, fat mass, and fasting acylcarnitine concentrations within and between the ad libitum LC diet group and the energy-matched HCC diet group.
DO  - 10.6083/m44q7tj2
DO  - DOI
AB  - Obesity is a public health concern with rising incidence and prevalence rates. Research exploring the metabolomic biomarkers for obesity suggests a potential association between elevated acylcarnitine concentrations in individuals with obesity compared to lean controls. Low-carbohydrate (LC) and high-complex-carbohydrate (HCC) dietary patterns are commonly followed by individuals with overweight and obesity seeking to lose weight. Yet, little is known about how these diets affect circulating acylcarnitine concentrations in combination with changes in body mass, lean mass, and fat mass.  
The goal of this secondary analysis of data obtained from the Comparison of Health Benefits and Risks of High-Carbohydrate, Low-Fat or Very-Low-Carbohydrate Diets for Weight Loss Study was to determine the effect of LC and HCC dietary interventions on circulating acylcarnitine concentrations among healthy adults with overweight and obesity. The first aim was to describe the impact of consuming a LC or HCC diet on fasting acylcarnitine concentrations at baseline and 2, 4, 6, and 18-weeks after dietary intervention. The second aim was to define the relationships between changes in lean mass, fat mass, and fasting acylcarnitine concentrations within and between the ad libitum LC diet group and the energy-matched HCC diet group.
T1  - Impact of high-complex-carbohydrate and low-carbohydrate diets and resulting body mass loss on circulating acylcarnitine concentrations in healthy adults with overweight and obesity
DA  - 2017
AU  - Attema, Kathryn J.
L1  - https://digitalcollections.ohsu.edu/record/7601/files/Attema.Kathryn.2017.pdf
PB  - Oregon Health and Science University
PY  - 2017
ID  - 7601
L4  - https://digitalcollections.ohsu.edu/record/7601/files/Attema.Kathryn.2017.pdf
KW  - Carnitine
KW  - Obesity
KW  - Body Composition
KW  - Weight Loss
KW  - low carbohydrate diet
KW  - fat restricted diet
TI  - Impact of high-complex-carbohydrate and low-carbohydrate diets and resulting body mass loss on circulating acylcarnitine concentrations in healthy adults with overweight and obesity
Y1  - 2017
L2  - https://digitalcollections.ohsu.edu/record/7601/files/Attema.Kathryn.2017.pdf
LK  - https://digitalcollections.ohsu.edu/record/7601/files/Attema.Kathryn.2017.pdf
UR  - https://digitalcollections.ohsu.edu/record/7601/files/Attema.Kathryn.2017.pdf
ER  -